Cocaine measurement, urine
What is this test?
This test measures the amount or presence of cocaine and its metabolites in urine. It is used to detect and monitor cocaine abuse or toxicity.
What are other names for this test?
- Urine cocaine measurement
What are related tests?
Why do I need this test?
Laboratory tests may be done for many reasons. Tests are performed for routine health screenings or if a disease or toxicity is suspected. Lab tests may be used to determine if a medical condition is improving or worsening. Lab tests may also be used to measure the success or failure of a medication or treatment plan. Lab tests may be ordered for professional or legal reasons. You may need this test if you have:
- Overdose of cocaine
When and how often should I have this test?
When and how often laboratory tests are done may depend on many factors. The timing of laboratory tests may rely on the results or completion of other tests, procedures, or treatments. Lab tests may be performed immediately in an emergency, or tests may be delayed as a condition is treated or monitored. A test may be suggested or become necessary when certain signs or symptoms appear.
Due to changes in the way your body naturally functions through the course of a day, lab tests may need to be performed at a certain time of day. If you have prepared for a test by changing your food or fluid intake, lab tests may be timed in accordance with those changes. Timing of tests may be based on increased and decreased levels of medications, drugs or other substances in the body.
The age or gender of the person being tested may affect when and how often a lab test is required. Chronic or progressive conditions may need ongoing monitoring through the use of lab tests. Conditions that worsen and improve may also need frequent monitoring. Certain tests may be repeated to obtain a series of results, or tests may need to be repeated to confirm or disprove results. Timing and frequency of lab tests may vary if they are performed for professional or legal reasons.
How should I get ready for the test?
To prepare for giving a urine sample, be sure to drink enough fluids before the test, unless you have been given other instructions. Try not to empty your bladder before the test.
How is the test done?
To provide a sample of urine, you will be asked to urinate into a container. Fill the container as much as you can, but do not overfill it. Urine samples may also be taken from a catheter.
How will the test feel?
The amount of discomfort you feel will depend on many factors, including your sensitivity to pain. Communicate how you are feeling with the person doing the test. Inform the person doing the test if you feel that you cannot continue with the test.
This test usually causes no discomfort.
What should I do after the test?
After collecting a urine sample, close the container if it has a lid. Place the container where the healthcare worker asked you to put it. Clean your hands with soap and water.
What are the risks?
Urine: A urine test is generally considered safe. Talk to your healthcare worker if you have questions or concerns about this test.
What are normal results for this test?
Laboratory test results may vary depending on your age, gender, health history, the method used for the test, and many other factors. If your results are different from the results suggested below, this may not mean that you have a disease. Contact your healthcare worker if you have any questions. The following are considered to be normal results for this test:
- Negative screening test (immunoassay) for cocaine metabolite, benzoylecgonine:<300 ng/mL 
- Negative confirmatory test (GC-MS) for cocaine metabolite, benzoylecgonine: <150 ng/mL 
What might affect my test results?
Ecgonine methylester (EME) is a metabolite of cocaine produced by pseudocholinesterase. Qualitative or quantitative impairment in pseudocholinesterase will alter excretion of this metabolite .
What follow up should I do after this test?
Ask your healthcare worker how you will be informed of the test results. You may be asked to call for results, schedule an appointment to discuss results, or notified of results by mail. Follow up care varies depending on many factors related to your test. Sometimes there is no follow up after you have been notified of test results. At other times follow up may be suggested or necessary. Some examples of follow up care include changes to medication or treatment plans, referral to a specialist, more or less frequent monitoring, and additional tests or procedures. Talk with your healthcare worker about any concerns or questions you have regarding follow up care or instructions.
Where can I get more information?
- National Council on Alcoholism and Drug Dependence - http://www.ncadd.org
 Cone EJ, Sampson-Cone AH, Darwin WD, et al: Urine testing for cocaine abuse: metabolic and excretion patterns following different routes of administration and methods for detection of false-negative results. J Anal Toxicol 2003; 27(7):386-401.
 Preston KL, Epstein DH, Cone EJ, et al: Urinary elimination of cocaine metabolites in chronic cocaine users during cessation. J Anal Toxicol 2002; 26(7):393-400.
 Department of Health and Human Services: Department of health and human services substance abuse and mental health services administration mandatory guidelines for federal workplace drug testing programs. SAMHSA. Washington, DC. 1994. Available from URL: http://dwp.samhsa.gov/DrugTesting/. As accessed 10/9/2005.
 United Nations International Drug Control Programme: Recommended methods for the detection and assay of heroin, cannabinoids, cocaine, amphetamine, methamphetamine, and ring-substituted amphetamine derivatives in biological specimens, United Nations, New York, New York, 1995.
Last Updated: 4/4/2018