Health Guide

Pomelo juice

What is it?

Pomelo juice is similar to grapefruit juice and comes from a plant called pomelo.

Other names for pomelo juice include: Chinese grapefruit, shaddock, pumelo, pommelo, pompelmous.

Ask your doctor, nurse, or pharmacist if you need more information about pomelo juice or if any information in this leaflet concerns you.

Before Using:

Tell your doctor if you

  • are taking medicine or are allergic to any medicine (prescription or over-the-counter (OTC) or dietary supplement)
  • are pregnant or plan to become pregnant while using pomelo juice
  • are breastfeeding


Talk with your caregiver about how much pomelo juice you should take. The amount depends on the strength of the medicine and the reason you are taking pomelo juice. If you are using this medicine without instructions from your caregiver, follow the directions on the medicine bottle. Do not take more medicine or take it more often than the directions tell you to.

To store this medicine:

Keep all medicine locked up and away from children. Store medicine away from heat and direct light. Do not store your medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down and not work the way it should work. Throw away medicine that is out of date or that you do not need. Never share your medicine with others.

Drug and Food Interactions:

Do not take pomelo juice without talking to your doctor first if you are taking:

  • cyclosporine (Neoral(R), Sandimmune(R), Sandimmune IV(R), Sangcya(R)) (1)
  • sildenafil (Viagra(R), Revatio(R)) (2)


  • Before taking pomelo juice, tell your doctor if you are pregnant or breastfeeding

Side Effects:

Call your doctor right away if you have any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hand, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, or rash.
  • Erection that is painful or lasts longer than 4 hours.
  • Lightheadedness, dizziness, or fainting.

Other Side Effects:

You may have other side effects. Tell your doctor if you have side effects that you think are caused by pomelo juice.


1. Grenier J, Fradette C, Morelli G, et al: Pomelo juice, but not cranberry juice, affects the pharmacokinetics of cyclosporine in humans. Clin Pharmacol Ther 2006; 79(3):255-262.

2. Al-Ghazawi MA, Tutunji MS, & AbuRuz SM: The effects of pummelo juice on pharmacokinetics of sildenafil in healthy adult male Jordanian volunteers. Eur J Clin Pharmacol 2010; 66(2):159-163.

Last Updated: 7/4/2018
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