What is it?
Podophyllum is an herbal medicine used to treat warts and other skin problems.
Other names for Podophyllum include: Podophyllum emodi, Himalayan mayapple, American mandrake, Devil's apple, and Duck's foot.
Ask your doctor, nurse, or pharmacist if you need more information about this medicine or if any information in this leaflet concerns you.
Tell your doctor if you
- are taking medicine or are allergic to any medicine (prescription or over-the-counter (OTC) or dietary supplement)
- are pregnant or plan to become pregnant while using this medicine
- are breastfeeding
- have other health problems, such as high blood pressure or heart or blood vessel disease
Talk with your caregiver about how much Podophyllum you should take. The amount depends on the strength of the medicine and the reason you are taking Podophyllum. If you are using this medicine without instructions from your caregiver, follow the directions on the medicine bottle. Do not take more medicine or take it more often than the directions tell you to.
To store this medicine:
Keep all medicine locked up and away from children. Store medicine away from heat and direct light. Do not store your medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down and not work the way it should work. Throw away medicine that is out of date or that you do not need. Never share your medicine with others.
- Do not use Podophyllum if you are pregnant (4-6)
Stop taking your medicine right away and talk to your doctor if you have any of the following side effects. Your medicine may be causing these symptoms which may mean you are allergic to it.
- Breathing problems or tightness in your throat or chest
- Chest pain
- Skin hives, rash, or itchy or swollen skin
Other Side Effects:
You may have the following side effects, but this medicine may also cause other side effects. Tell your doctor if you have side effects that you think are caused by this medicine.
- Fast heart rate or light-headedness after getting up (1)
- Confusion, dizziness, hallucinations, unsteady walk, muscle weakness, seizure (1)
- Belly pain, unable to pass urine (1)
- Skin scarring, necrosis (tissue death) (7)
1: USPDI: Drug Information for the Health Care Professional, 20th ed. Micromedex, Inc, Englewood, CO; 2000.
2. Gowdey G, Lee RK & Carpenter WM: Treatment of HIV-related hairy leukoplakia with podophyllulm resin 25% resin solution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995; 79(1): 64-67.
3. Lozada-Nur F & Costa C: Retrospective findings of the clinical benefits of podophyllum resin 25% sol on hairy leukoplakia. Clinical results in nine patients. Oral Surg Oral Med Oral Pathol 1992; 73(5):555-558.
4. Blumenthal M, Busse WR, Goldberg A et al (eds): The Complete German Commission E Monographs, 1st ed. American Botanical Council, Austin, TX; 1998.
5. Briggs GG, Freeman RK & Yaffe SJ: Drugs in Pregnancy and Lactation, 5th ed. Williams and Wilkins, Baltimore, MD; 1998.
6. McGuffin M, Hobbs C, Upton R et al (eds): American Herbal Products Association's Botanical Safety Handbook. CRC Press, Boca Raton, FL; 1997.
7. Fisher AA: Severe systemic and local reactions to topical podophylllum resin. Cutis 1981; 28(3):233-266.
Last Updated: 5/4/2018