Health Guide

Green lipped mussel

What is it?

Green lipped mussel is a dietary supplement used for arthritis, asthma, menstrual (monthly) pain, multiple sclerosis, and skin problems like psoriasis and atopic dermatitis. It may also be used to treat inflammatory bowel disease.

Other names for Green lipped mussel include: Perna canaliculus , Lyprinol(R), Seatone, and New Zealand green lipped mussel.

Ask your doctor, nurse, or pharmacist if you need more information about this medicine or if any information in this leaflet concerns you.

Before Using:

Tell your doctor if you

  • are taking medicine or are allergic to any medicine (prescription or over-the-counter (OTC) or dietary supplement)
  • are pregnant or plan to become pregnant while using this medicine
  • are breast feeding
  • have other health problems, such as high blood pressure or heart or blood vessel disease


Talk with your doctor, pharmacist, or nurse about how much Green lipped mussel you should take. The amount depends on the strength of the medicine and the reason you are taking Green lipped mussel. If you are using this medicine without instructions from your caregiver, follow the directions on the label. Do not take more Green lipped mussel or take it more often than what is written on the directions.

To store this medicine:

Keep all medicine locked up and away from children. Store medicine away from heat and direct light. Do not store your medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down and not work the way it should work. Throw away medicine that is out of date or that you do not need. Never share your medicine with others.


  • Before taking Green lipped mussel, tell your doctor if you are pregnant or breast feeding
  • Green lipped mussel can be contaminated with heavy metals (5) or shellfish toxins (6)

Side Effects:

Stop taking your medicine right away and talk to your doctor if you have any of the following side effects.

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, or rash.

Other Side Effects:

You may have the following side effects, but this medicine may also cause other side effects. Tell your doctor if you have side effects that you think are caused by this medicine.

  • Upset stomach and gas (2)
  • Asthma (3)
  • Skin rash (4)
  • You may retain fluid while taking Green lipped mussel (1)


1. Gibson S & Gibson R: The treatment of arthritis with a lipid extract of Perna canaliculus: a randomized trial. Comp Ther Med 1998; 6(3):122-126.

2. Gibson RG & Gibson SL: Green-lipped mussel extract in arthritis. Lancet 1981; 1(8217):439.

3. Glass W, Power P, Fishwick D et al: Work-related respiratory symptoms and lung function in New Zealand mussel openers. Am J Ind Med 1998; 34(2):163-168.

4. Caughey D, Grigor R, Caughey E et al: Perna canaliculus in the treatment of rheumatoid arthritis. Eur J Rheum Inflam 1983; 6(2):197-200.

5. Morohashi A, Satake M, Naoki H et al: Brevetoxin B4 isolated from greenshell mussels Perna canaliculus, the major toxin involved in neurotoxic shellfish poisoning in New Zealand. Nat Toxins 1999; 7(2):45-48.

6. Wong CK, Wong PP & Chu LM: Heavy metal concentrations in marine fishes collected from fish culture sites in Hong Kong. Arch Environ Contam Toxicol 2001; 40(1):60-69.

Last Updated: 7/4/2018
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