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Androstenedione

What is it?

Androstenedione is banned by the Food and Drug Administration (FDA). It has been used to increase muscle mass, improve strength, improve athletic performance, and increase testosterone (male sex hormone) as an alternative to anabolic steroids.

Other names for Androstenedione include: Andro, Androstene, and Androst-4-ene-3,17-dione.

Ask your doctor, nurse, or pharmacist if you need more information about this medicine or if any information in this leaflet concerns you.

Before Using:

Tell your doctor if you

  • are taking medicine or are allergic to any medicine (prescription or over-the-counter (OTC) or dietary supplement)
  • are pregnant or plan to become pregnant while using this medicine
  • are breastfeeding
  • have any other health problems, such as high blood pressure, liver or kidney problems, or heart or blood vessel disease

Dosage:

Androstenedione is banned by the Food and Drug Administration (FDA). You should not take androstenedione as it is not safe.

To store this medicine:

Androstenedione is banned by the Food and Drug Administration (FDA).

Drug and Food Interactions:

Do not take Androstenedione without talking to your doctor first if you are taking:

  • Testosterone (Testoderm(R), Androderm(R), Androgel(R))

Warnings:

  • Before taking Androstenedione, tell your doctor if you are pregnant or breastfeeding
  • Long term use may affect liver function
  • Women with a family history of or who have had breast cancer should only take this supplement after talking to their doctor (5)
  • Men with prostate problems should only take this supplement after talking to their doctor (5)

Side Effects:

Stop taking your medicine right away and talk to your doctor if you have any of the following side effects. Your medicine may be causing these symptoms which may mean you are allergic to it.

  • Breathing problems or tightness in your throat or chest
  • Chest pain
  • Skin hives, rash, or itchy or swollen skin

Other Side Effects:

You may have the following side effects, but this medicine may also cause other side effects. Tell your doctor if you have side effects that you think are caused by this medicine.

  • Headache (6)
  • Aggressive behavior, mood swings, and bad moods (6)
  • Excessive use can cause slow growth (7)
  • Increased sex drive (8)
  • Increase in body and facial hair (9)
  • Acne (6)
  • Hair loss (6)
  • Your skin may become more sensitive to the sun and may burn easier (10)
  • Breast growth in men, liver problems, or testicles that are getting smaller can occur (11)

References:

1. Anon: Androstenedione usage, Jan 22, 1999 (cited 9/1/1999). Available at: http://www.betterbodz.com/useandro.html

2. Anon: Androstenedione (cited 9/1/1999). Available at: http://www.valuenut.com/ANDROSTENEDIONE.htm

3. Anon: Androstenedione, June 23, 1999 (cited 9/1/1999). Available at: http://www.healthgate.com/healthy/man/1998/creatine_andro/page2/shtml

4. Androstenedione recommended usage (cited 9/1/1999). Available at: http://www.dheahealth.com/andros/usage.html

5. Anon: Androstenedione, August 23, 1999 (cited 9/1/1999). Available at: http://www.vermontnutrition.com/androinfo.html

6. Colgan M: Androstenedione and tales of testosterone, Oct 1998 (cited 9/1/1999). Available at: http://www.musculardevelopment.com/oct/andro1.html

7. FDA: Sample warning letter on androstenedione. March 11, 2004.

Available at http://www.cfsan.fda.gov/~dms/andltr.html (cited 04/2004).

8. Markel D, Kaplan N & Fishel M: The Andro debate (cited 9/1/1999). Available at: http://www.angelfire.com/tx2/andro/

9. Anon: Consumer review: I am a female who uses andro to increase my sex drive (cited 9/2/1999). Available at: http://www.nutritionalsupplements.com/androsex.html

10. Mahesh VB & Greenblatt BB: The in-vivo conversion of dehydroepiandrosterone and androstenedione to testosterone in the human. Acta Endocrinol 1962; 41: 400-406.

11. Anon: Consumer review: Androstenedione and creatine have given me increased stamina, mass, and sunburns (cited 9/2/1999). Available at: http://www.nutritionalsupplements.com/andro/57r.html

12. Zurer P: Androstenedione: out of the park or out left field? Science Insights 1998; 76: 102-104.

13. Weisser H & Krieg M: In vitro inhibition of androstenedione 5-alpha-reduction by finasteride in epithelium and stroma of human benign prostatic hyperplasia. J Steroid Biochem Mol Biol 1998; 67(1): 49-55.

14. Cummings EA, Salisbury SR, Givner ML et al: Testosterone - associated high androgen levels, a pharmacologic effect or a laboratory artifact? J Clin Endocrinol Metab 1998; 83(3):784-787.


Last Updated: 9/4/2017
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