Health Guide


What is it?

Phosphatidylserine is a naturally occurring phospholipid found in our bodies. It is also found in small amounts in lecithin and common foods. It is used as a supplement in Alzheimer's disease, depression, to improve memory and thought processes, and by athletes in training.

Other names for Phosphatidylserine include: BC-PS, Phos Serine, Cephalin, Kephalin, and Phosphatidylserine.

Ask your doctor, nurse, or pharmacist if you need more information about this medicine or if any information in this leaflet concerns you.

Before Using:

Tell your doctor if you

  • are taking medicine or are allergic to any medicine (prescription or over-the-counter (OTC) or dietary supplement)
  • are pregnant or plan to become pregnant while using this medicine
  • are breastfeeding
  • have any other health problems, such as high blood pressure or heart or blood vessel disease


Talk with your caregiver about how much Phosphatidylserine you should take. The amount depends on the strength of the medicine and the reason you are taking Phosphatidylserine. If you are using this medicine without instructions from your caregiver, follow the directions on the medicine bottle. Do not take more medicine or take it more often than the directions tell you to.

To store this medicine:

Keep all medicine locked up and away from children. Store medicine away from heat and direct light. Do not store your medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down and not work the way it should work. Throw away medicine that is out of date or that you do not need. Never share your medicine with others.


  • Before taking Phosphatidylserine, tell your doctor if you are pregnant or breastfeeding

Side Effects:

Stop taking your medicine right away and talk to your doctor if you have any of the following side effects. Your medicine may be causing these symptoms which may mean you are allergic to it.

  • Breathing problems or tightness in your throat or chest
  • Chest pain
  • Skin hives, rash, or itchy or swollen skin

Other Side Effects:

You may have the following side effects, but this medicine may also cause other side effects. Tell your doctor if you have side effects that you think are caused by this medicine.

  • Side effects are rare but may include nausea, upset stomach, or trouble falling asleep if Phosphatidylserine is taken before bed (7,8)


1. Murray, MT: Encyclopedia of Nutritional Supplements. Prima Publishing, Rocklin, CA; 1996.

2. Cenacchi T et al: Cognitive decline in the elderly: A double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration. Aging 1993; 5:123-133.

3. Crook T et al: Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992; 28:61-66.

4. Funfgeld EW et al: Double-blind study with phosphatidylserine (PS) in parkinsonian patients with senile dementia of Alzheimer's type (SDAT). Prog Clin Biol Res 1989; 317:1235-1246.

5. Maggioni M et al: Effects of phosphatidylserine therapy in geriatric patients with depressive disorders. Acta Psychiatr Scand 1990; 81:265-270.

6. Burke ER & Fahey TD: Phosphatidylserine (PS): Promise for Athletic Performance. Keats Publishing, New Canaan, CT; 1998.

7. Monteverde A, Gnemmi P, Rossi F et al: Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin Thera 1990; 12(4):315-322.

8. Pepping J: Alternative therapies. Am J Health-Syst Pharm 1999; 56:1-5.

Last Updated: 7/4/2018
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