Health Guide


What is it?

Proanthocyanidins are a type of bioflavonoids that are used to treat varicose veins, venous insufficiency (poor circulation problems), diabetic retinopathy, and macular degeneration.

Other names for Proanthocyanidins include: PCO, Grape Seed Extract, and Pine Bark Extract.

Ask your doctor, nurse, or pharmacist if you need more information about this medicine or if any information in this leaflet concerns you.

Before Using:

Tell your doctor if you

  • are taking medicine or are allergic to any medicine (prescription or over-the-counter (OTC) or dietary supplement)
  • are pregnant or plan to become pregnant while using this medicine
  • are breastfeeding
  • have any other health problems, such as high blood pressure or heart or blood vessel disease


Talk with your caregiver about how much Proanthocyanidins you should take. The amount depends on the strength of the medicine and the reason you are taking Proanthocyanidins. If you are using this medicine without instructions from your caregiver, follow the directions on the medicine bottle. Do not take more medicine or take it more often than the directions tell you to.

To store this medicine:

Keep all medicine locked up and away from children. Store medicine away from heat and direct light. Do not store your medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down and not work the way it should work. Throw away medicine that is out of date or that you do not need. Never share your medicine with others.


  • Before taking Proanthocyanidins, tell your doctor if you are pregnant or breastfeeding

Side Effects:

Stop taking your medicine right away and talk to your doctor if you have any of the following side effects. Your medicine may be causing these symptoms which may mean you are allergic to it.

  • Breathing problems or tightness in your throat or chest
  • Chest pain
  • Skin hives, rash, or itchy or swollen skin

Other Side Effects:

This medicine may also cause other side effects. Tell your doctor if you have side effects that you think are caused by this medicine.


1. Murray, MT: Encyclopedia of Nutritional Supplements. Prima Publishing, Rocklin, CA; 1996.

2. Hertog MG, Feskens JM, Hollman PC et al: dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 1993;342:1007-1011.

3. Wergorwski J, Robert AM & Moczar M: The effect of procyanidolic oligomers on the composition of normal and hypercholesterolemic rabbit aortas. Biochem Pahrmacol 1984;33:3491-3497.

4. Chang WC and HSU FL: inhibition of platelet aggregation and arachidontae metabolism in platelets by procyanidins. Prostagland Leukotri Essential Fatty Acids 1989;38:181-188.

5. Meunier MT Ville F, Jonadet M et al: Inhibition of angiotensin I converting enzyme by flavanolic compounds, in vitro and in vivo studies. Planta Medica 1987;54: 12-15.

Last Updated: 7/4/2018
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.

All rights reserved