Health Guide

Gamma oryzanol

What is it?

Gamma Oryzanol is a substance found in grains. It is used to decrease cholesterol (fat) in the blood and to treat skin rashes in children. It is also used to treat an underactive (slow) thyroid gland. Women who are going through menopause (change of life) may use Gamma Oryzanol to treat hot flashes.

Other names for Gamma Oryzanol include: Calclate, Gamma-oz, Gammariza, Oryzanol, Oz, and Thiaminogen.

Ask your doctor, nurse, or pharmacist if you need more information about this medicine or if any information in this leaflet concerns you.

Before Using:

Tell your doctor if you

  • are taking medicine or are allergic to any medicine (prescription or over-the-counter (OTC) or dietary supplement)
  • are pregnant or plan to become pregnant while using this medicine
  • are breastfeeding
  • have any other health problems, such as high blood pressure or heart or blood vessel disease


Talk with your caregiver about how much Gamma Oryzanol you should take. The amount depends on the strength of the medicine and the reason you are taking Gamma Oryzanol. If you are using this medicine without instructions from your caregiver, follow the directions on the medicine bottle. Do not take more medicine or take it more often than the directions tell you to.

To store this medicine:

Keep all medicine locked up and away from children. Store medicine away from heat and direct light. Do not store your medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down and not work the way it should work. Throw away medicine that is out of date or that you do not need. Never share your medicine with others.


  • Before taking Gamma Oryzanol, tell your doctor if you are pregnant or breastfeeding

Side Effects:

Stop taking your medicine right away and talk to your doctor if you have any of the following side effects. Your medicine may be causing these symptoms which may mean you are allergic to it.

  • Breathing problems or tightness in your throat or chest
  • Chest pain
  • Skin hives, rash, or itchy or swollen skin

Other Side Effects:

This medicine may also cause other side effects. Tell your doctor if you have side effects that you think are caused by this medicine.


1. Murray, MT: Encyclopedia of Nutritional Supplements. Prima Publishing, Rocklin, CA; 1996.

2. Ishihara M: Effect of gamma-oryzanol on serum lipid peroxide levels and climacteric disturbances. Asia Oceania J Obstet Gynecol 1984;10:317.

3. Ishihara M, Hieda S, Higuchi K et al: Effect of gamma-oryzanol on serum lipid peroxide level of patients with climacteric disturbance. J Aichi Med Univ Assoc 1983; 11(3):278-285.

4. Sasaki J, Takada Y, Handa K et al: Effects of gamma-oryzanol on serum lipids and apoliproproteins in dyslipidemic schizophrenics receiving major tranquilizers. Clin Therapeutics 1990; 12(3):263-268.

5. Yoshino G, Kazumi T, Amano M et al: Effects of gamma-oryzanol and probucol on hyperlipidemia. Curr Ther Res 1989; 45(6):975-982.

6. Yoshino G, Kazumi T, Amano M et al: Effects of gamma oryzanol on hyperlipidemic subjects. Curr Ther Res 1989; 45(4):543-552.

Last Updated: 7/4/2018
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