Health Guide


What is it?

Histidine is an amino acid that is used as a supplement for the treatment of arthritis and too much stomach acid.

Other names for Histidine include: L-Histidine.

Ask your doctor, nurse, or pharmacist if you need more information about this medicine or if any information in this leaflet concerns you.

Before Using:

Tell your doctor if you

  • are taking medicine or are allergic to any medicine (prescription or over-the-counter (OTC) or dietary supplement)
  • are pregnant or plan to become pregnant while using this medicine
  • are breastfeeding
  • have any other health problems, such as high blood pressure or heart or blood vessel disease


Talk with your caregiver about how much Histidine you should take. The amount depends on the strength of the medicine and the reason you are taking Histidine. If you are using this medicine without instructions from your caregiver, follow the directions on the medicine bottle. Do not take more medicine or take it more often than the directions tell you to.

To store this medicine:

Keep all medicine locked up and away from children. Store medicine away from heat and direct light. Do not store your medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down and not work the way it should work. Throw away medicine that is out of date or that you do not need. Never share your medicine with others.


  • Before taking Histidine, tell your doctor if you are pregnant or breastfeeding
  • Histidine should not be used in doses greater than 1.5 grams daily without first talking to your health care giver (1)

Side Effects:

Stop taking your medicine right away and talk to your doctor if you have any of the following side effects. Your medicine may be causing these symptoms which may mean you are allergic to it.

  • Breathing problems or tightness in your throat or chest
  • Chest pain
  • Skin hives, rash, or itchy or swollen skin

Other Side Effects:

This medicine may also cause other side effects. Tell your doctor if you have side effects that you think are caused by this medicine.


1. Hendler SS: The Doctors' Vitamin and Mineral Encyclopedia. Fireside Press, New York, NY; 1990.

2. Gerber DA, Gerber MG: Treatment of rheumatoid arthritis with histidine. Clinical Research. 1969;17:351.

3. Gerber DA, Gerber MG: Specificity of a low free histidine concentration for rheumatoid arthritis. J Chron Dis 1977;30:115.

Last Updated: 7/4/2018
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