Health Guide


What is it?

Pyruvate is created in the body during the metabolism of carbohydrates and proteins (necessary nutrients for the body contained in foods). It is used as a supplement for weight loss, high blood pressure, diabetes, cataracts, and to increase athletic performance.

Other names for Pyruvate include: Pyruvic Acid.

Ask your doctor, nurse, or pharmacist if you need more information about this medicine or if any information in this leaflet concerns you.

Before Using:

Tell your doctor if you

  • are taking medicine or are allergic to any medicine (prescription or over-the-counter (OTC) or dietary supplement)
  • are pregnant or plan to become pregnant while using this medicine
  • are breastfeeding
  • have any other health problems, such as high blood pressure or heart or blood vessel disease


Talk with your caregiver about how much Pyruvate you should take. The amount depends on the strength of the medicine and the reason you are taking Pyruvate. If you are using this medicine without instructions from your caregiver, follow the directions on the medicine bottle. Do not take more medicine or take it more often than the directions tell you to.

To store this medicine:

Keep all medicine locked up and away from children. Store medicine away from heat and direct light. Do not store your medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down and not work the way it should work. Throw away medicine that is out of date or that you do not need. Never share your medicine with others.


  • Before taking Pyruvate, tell your doctor if you are pregnant or breastfeeding

Side Effects:

Stop taking your medicine right away and talk to your doctor if you have any of the following side effects. Your medicine may be causing these symptoms which may mean you are allergic to it.

  • Breathing problems or tightness in your throat or chest
  • Chest pain
  • Skin hives, rash, or itchy or swollen skin

Other Side Effects:

You may have the following side effects, but this medicine may also cause other side effects. Tell your doctor if you have side effects that you think are caused by this medicine.

  • Gas, bloating, and diarrhea may occur if you take large amounts of Pyruvate (1)
  • Nausea (upset stomach) and vomiting (throwing up) (8)


1. Lininger S (ed): The Natural Pharmacy. Prima Health Publishing, Rocklin, CA; 1998.

2. Stanko RT, Tietze DL & Arch JE: Body composition, energy utilization, and nitrogen metabolism with a 4.25-MJ/d low-energy diet supplemented with pyruvate. AM J Clin Nurt 1992; 56(4):630-635.

3. Stanko RT, Reynolds HR, Hoyson R et al: Pyruvate supplementation of a low-cholesterol, low-fat diet: Effects on plasma lipid concentration and body composition in hyperlipidemic patients. AM J Clin Nutr 1994; 59:423-427.

4. Ivy JL, Cortez MY, Chandler RM et al: Effects of pyruvate on the metabolism and insulin resistance of obese Zucker rats. Am J Clin Nutr 1994; 59:331-337.

5. Stanko RT, Robertson RJ, Galbreath RW et al: Enhanced leg exercise endurance with a high-carbohydrate diet and dihyroxyacetone and pyruvate. J Apl Phys 1990; 69(5):1651-1656.

6. Stanko RT, Robertson RJ, Spina RJ et al: Enhancement of arm exercise endurance capacity with dihydroxyacetone and pyruvate. J Appl Phys 1990; 68(1):119-124.

7. Kalman D, Colker CM, Wilets I et al: The effects of pyruvate supplementation on body composition in overweight individuals. Nutrition 1999; 15(5):337-340.

8. Morrison MA, Spriet LL & Dyck DJ: Pyruvate ingestion for 7 days does not improve aerobic performance in well-trained individuals. J Appl Physiol 2000; 89: 549-556.

Last Updated: 5/4/2018
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