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Health Guide

Sugammadex (Intravenous route)

Pronunciation:

soo-GAM-ma-dex

Brand Names:

  • Bridion

Dosage Forms:

  • Solution

Classifications:

Therapeutic—

Nondepolarizing Muscle Relaxant Antagonist

Uses of This Medicine:

Sugammadex injection is used to reverse the effects of the muscle relaxants rocuronium and vecuronium, which are given to adult patients during surgery.

This medicine is to be given by or under the supervision of your doctor.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies have not been performed on the relationship of age to the effects of sugammadex injection in the pediatric population. Safety and efficacy have not been established.

Older adults—

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of sugammadex injection in the elderly. However, elderly patients are more likely to have kidney problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Desogestrel
  • Dienogest
  • Drospirenone
  • Estradiol
  • Ethinyl Estradiol
  • Ethynodiol
  • Etonogestrel
  • Gestodene
  • Levonorgestrel
  • Mestranol
  • Norethindrone
  • Norgestimate
  • Norgestrel
  • Toremifene

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Anemia or
  • Bleeding problems or
  • Bradycardia (slow heartbeat)—May increase risk for more serious side effects.
  • Kidney disease, severe—Use is not recommended in these patients.

Proper Use of This Medicine:

A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle placed in one of your veins.

Precautions While Using This Medicine:

Your doctor will check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood tests may be needed to check for unwanted effects.

This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Bradycardia may occur after receiving this medicine. Tell your doctor right away if you have chest pain or discomfort, lightheadedness, dizziness or fainting, shortness of breath, slow or irregular heartbeat, or unusual tiredness.

This medicine may increase your risk of bleeding problems. Tell your doctor right away if you have sudden or severe headache, problems with vision, speech, or walking, or unusual bleeding or bruising.

Birth control pills may not work while you are receiving sugammadex. To keep from getting pregnant, use another form of birth control for up to 7 days after your last treatment. Other forms of birth control include condom, a diaphragm, or contraceptive foam or jelly.

Before you have any medical tests, tell the medical doctor in charge that you were given this medicine. The results of some tests may be affected by this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
Blurred vision
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
headache
nervousness
pounding in the ears
slow or fast heartbeat
sweating
unusual tiredness or weakness
Less common
Chest pain or discomfort
chills
fever
shortness of breath
Incidence not known
Blue lips and fingernails
confusion
cough
difficult, fast, noisy breathing, sometimes with wheezing
difficulty with breathing
difficulty with swallowing
feeling of warmth
hives or welts, itching, or rash
hoarseness
increased sweating
irritation
joint pain, stiffness, or swelling
pale skin
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
redness of the face, neck, arms, and occasionally, upper chest
severe, sudden headache
swelling in the legs and ankles
unusual bleeding or bruising

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Abdominal or stomach pain
cough
headache
nausea
pain at the injection site
pain in the arms or legs
vomiting
Less common
Bloated
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
dry mouth
feeling sad or empty
full feeling
irritability
joint or muscle pain
lack of appetite
loss of interest or pleasure
passing gas
restlessness
sore throat
tiredness
trouble concentrating
trouble sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 9/4/2017
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