HealthSearch

Health Guide

Elotuzumab (Intravenous route)

Pronunciation:

el-oh-TOOZ-ue-mab

Brand Names:

  • Empliciti

Dosage Forms:

  • Powder for Solution

Classifications:

Therapeutic—

Antineoplastic Agent

Pharmacologic—

Monoclonal Antibody

Uses of This Medicine:

Elotuzumab injection is used together with other medicines to treat multiple myeloma (a blood cell cancer) in patients who have received prior treatments. It interferes with the growth of cancer cells, which are then destroyed by the body. Elotuzumab is an antineoplastic agent (cancer medicine).

This medicine is to be given only by or under the direct supervision of your doctor.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies have not been performed on the relationship of age to the effects of elotuzumab injection in the pediatric population. Safety and efficacy have not been established.

Older adults—

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of elotuzumab injection in the elderly.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Infection—May decrease your body's ability to fight infections.
  • Liver disease—Use with caution. May make this condition worse.

Proper Use of This Medicine:

Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all of the risks and benefits. It is important for you to work closely with your doctor during your treatment.

You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins.

Your doctor may give you some medicines (eg, acetaminophen, diphenhydramine, ranitidine) to prevent infusion reactions.

This medicine should come with a patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Precautions While Using This Medicine:

It is very important that your doctor check you at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine together with lenalidomide while you are pregnant can harm your unborn baby. Men and women should use an effective form of birth control to prevent pregnancy during treatment. If you think a pregnancy has occurred while using the medicine, tell your doctor right away.

Infusion reactions may occur with this medicine. Tell your doctor right away if you have a skin rash, dizziness, fever or chills, a headache, nausea or vomiting, a slow or fast heartbeat, lightheadedness or fainting, sweating, or unusual tiredness or weakness.

Call your doctor right away if you have a cough that won't go away, weight loss, night sweats, fever, chills, or flu-like symptoms, such as a runny or stuffy nose, headache, or blurred vision. These may be symptoms of an infection.

Using this medicine may increase your risk of getting other types of cancer (including skin cancer). Talk to your doctor if you have concerns about this risk.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
Blurred vision
body aches or pain
chest pain
chills
confusion
cough or hoarseness
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
ear congestion
facial swelling
fever or chills
headache
hives, itching, or rash
hoarseness
irritation
joint pain, stiffness, or swelling
loss of voice
lower back or side pain
nasal congestion
nausea or vomiting
nervousness
painful or difficult urination
pounding in the ears
redness of the skin
runny nose
slow or fast heartbeat
sneezing
sore throat
sweating
swelling of the eyelids, face, lips, hands, or feet
tightness in the chest
troubled breathing or swallowing
unusual tiredness or weakness
Less common
Abdominal pain or tenderness
clay-colored stools
dark urine
loss of appetite
persistent sore that does not heal
pink skin growth
reddish patch or irritated area
shiny skin bump
swelling of the feet or lower legs
white, yellow or waxy scar-like area on the skin
yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Blindness
burning, numbness, tingling, or painful sensations
decreased appetite
decreased vision
decreased weight
diarrhea
difficulty having a bowel movement (stool)
muscle aches
night sweats
pain in the arms or legs
unsteadiness or awkwardness
weakness in the arms, hands, legs, or feet

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 9/4/2017
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.

Truven Health Analytics. All rights reserved.

Thomson & A.D.A.M