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Health Guide

Ioversol (Injection route)

Pronunciation:

eye-oh-VER-sol

Brand Names:

  • Optiray 160
  • Optiray 240
  • Optiray 300
  • Optiray 320
  • Optiray 350

Dosage Forms:

  • Solution

Warnings:

Injection route(Solution)

Not for intrathecal useInadvertent intrathecal administration may cause death, convulsions, cerebral hemorrhage, coma, paralysis, arachnoiditis, acute renal failure, cardiac arrest, seizures, rhabdomyolysis, hyperthermia, and brain edema .

Classifications:

Therapeutic—

Radiological Non-Ionic Contrast Media

Uses of This Medicine:

Ioversol injection is used to help diagnose or find problems in the brain, heart, head, blood vessels, and other parts of the body. It is an iodinated contrast agent. Contrast agents are used to create a clear picture of the different parts of the body during certain medical procedures such as CT scans and angiography.

This medicine is to be given only by or under the supervision of a doctor.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of Optiray™ 350 and Optiray™ 320 for angiography, and Optiray™ 320 for CT scan of the head and body in children. However, safety and efficacy have not been established in newborns.

Older adults—

Appropriate studies on the relationship of age to the effects of ioversol injection have not been performed in the geriatric population. However, no geriatric-specific problems have been documented to date.

Pregnancy—

Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Metformin

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergic rhinitis (hay fever) or
  • Allergy to a contrast agent, history of or
  • Allergy to iodine or
  • Asthma—Use with caution. May increase risk of having allergic reactions.
  • Anuria (not able to pass urine) or
  • Blood vessel disease, severe or
  • Congestive heart failure or
  • Dehydration or
  • Diabetes or
  • Kidney disease or
  • Multiple myeloma (cancer of plasma cells) or
  • Paraproteinemia (high amount of paraprotein in the blood)—May increase risk of having kidney failure.
  • Blood clotting problems (eg, phlebitis, thrombosis) or
  • Heart or blood vessel disease (eg, arteriosclerosis) or
  • Hypertension (high blood pressure) or
  • Kidney disease, severe or
  • Liver disease or
  • Pheochromocytoma (adrenal problem) or
  • Sickle cell disease (inherited blood disorder)—Use with caution. May make these conditions worse.
  • Homocystinuria (genetic disease)—Patients with this condition should avoid undergoing angiography because of the increase risk of having blood clotting problems.
  • Hyperthyroidism (overactive thyroid)—Should not be used in patients with this condition.

Proper Use of This Medicine:

A doctor or other trained health professional will give you or your child this medicine in a hospital. This medicine is given through a needle placed in an artery or a vein.

Drink extra fluids so you will pass more urine while you or your child are receiving this medicine. This may help prevent kidney problems.

Precautions While Using This Medicine:

It is very important that your doctor check the progress of you or your child closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.

This medicine may cause heart attack, stroke, and blood clotting problems during angiographic procedures. Tell your doctor right away if you have chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, nausea, unusual sweating, faintness, coughing up blood, numbness or weakness in your arm or leg, or on one side of your body, sudden or severe headache, or problems with vision, speech, or walking after receiving this medicine.

Severe kidney problems may occur after receiving this medicine. This is more likely to occur if you receive too much of this medicine. Tell your doctor right away if you or your child have the following symptoms after receiving the medicine: agitation, confusion, decreased urine output, dizziness, headache, muscle twitching, rapid weight gain, or swelling of the face, ankles, or hands.

This medicine may cause a serious type of allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor or nurse right away if you or your child has a skin rash, itching, shortness of breath, sweating, swelling of the face, tongue, and throat, or tightness in the chest after you get the injection.

Serious skin reactions can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are receiving this medicine.

Check with your doctor right away if you have a fever, chills, cough, sore throat, swollen, painful, or tender lymph glands in the neck, armpit, or groin, or yellow skin or eyes while using this medicine. These could be symptoms of a serious condition called drug reaction with eosinophilia and systemic symptoms (DRESS).

Tell your doctor right away if you or your child have mild, burning pain, feeling of warmth or coldness, peeling of the skin, redness, or swelling at the injection site.

Make sure your doctor knows if you or your child have had an allergic reaction to any dye or medicine given during a test or procedure.

While using this medicine, you may be exposed to radiation. Talk with your doctor if you have concerns about this.

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Rare
Arm, back, or jaw pain
blood in the stools or urine
blue lips and fingernails
blurred vision
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
bruising
changes in skin color
chest pain or discomfort
chest tightness or heaviness
confusion
coughing
coughing or vomiting blood
coughing that sometimes produces a pink frothy sputum
decrease in the frequency of urination
decrease in urine volume
difficult, fast, noisy breathing
difficulty in passing urine (dribbling)
difficulty with swallowing
dizziness or lightheadedness
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
fainting
feeling of constant movement of self or surroundings
headache
hives or welts, itching, or skin rash
hoarseness
increased sweating
nausea
nervousness
painful urination
pains in the chest, groin, or legs, especially calves of the legs
pain, tenderness, or swelling of the foot or leg
pale skin
persistent bleeding or oozing from the puncture sites, mouth, or nose
pounding in the ears
rapid weight gain
redness of the skin
seizures
sensation of spinning
severe headaches of sudden onset
severe numbness, especially on one side of the face or body
severe, unusual tiredness or weakness
slow, fast, or irregular heartbeat
slow or irregular breathing
stupor
sudden loss of coordination
sudden onset of shortness of breath for no apparent reason
sudden onset of slurred speech
sudden vision changes
sweating
swelling around the eyes
swelling in the legs and ankles
unusual tiredness or weakness
Incidence not known
Agitation
blistering, peeling, or loosening of the skin
chills
coma
confusion
depression
diarrhea
extremely high fever or body temperature
fast, shallow breathing
fast, weak heartbeat
fever
hostility
irritability
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
lethargy
muscle cramps
muscle twitching
no sensation in the legs
not able to pass urine
pale, clammy skin
red, irritated eyes
sore throat
sores, ulcers, or white spots in the mouth or on the lips
tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area
thirst
unable to move the legs

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare
Bad taste
collection of blood under the skin
deep, dark purple bruise
dry mouth
pain, redness, or pale skin at the injection site
ringing in the ears
vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 9/4/2017
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