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Iohexol (Injection route, oral route, rectal route)

Pronunciation:

eye-oh-HEX-ol

Brand Names:

  • Omnipaque 140
  • Omnipaque 180
  • Omnipaque 240
  • Omnipaque 300
  • Omnipaque 350
  • Omnipaque Flexipak

Dosage Forms:

  • Solution

Classifications:

Therapeutic—

Radiological Non-Ionic Contrast Media

Uses of This Medicine:

Iohexol injection is used to help diagnose or find problems in the brain, back, heart, head, blood vessels, and other parts of the body. It is an iodinated contrast agent. Contrast agents are used to create a clear picture of the different parts of the body during certain medical procedures such as CT scans and angiography.

Iohexol may also be given orally or rectally to help diagnose or find problems in the joints, stomach or intestines, pancreas, and other parts of the body.

This medicine is to be given only by or under the supervision of a doctor.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of iohexol in children. Some pediatric patients with certain medical conditions may have more unwanted side effects which may require caution in patients receiving iohexol.

Older adults—

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of iohexol in the elderly. However, elderly patients are more likely to have unwanted side effects which may require caution in patients receiving iohexol.

Pregnancy—

Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast-feeding—

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Metformin

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Amiodarone

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse or
  • Heart or blood vessel disease or
  • Multiple sclerosis or
  • Seizures or epilepsy, history of—Iohexol injection should be used with caution in these patients.
  • Allergies or hypersensitivities, or
  • Allergic rhinitis (hay fever) or
  • Allergy to a contrast agent, history of or
  • Allergy to food or
  • Allergy to iodine or
  • Asthma—Use with caution. May increase risk of having allergic reactions.
  • Anuria (not able to pass urine) or
  • Blood vessel disease, severe or
  • Congestive heart failure or
  • Dehydration or
  • Diabetes or
  • Diabetic nephropathy or
  • Kidney disease or
  • Multiple myeloma (cancer of plasma cells) or
  • Paraproteinemia (high amount of paraprotein in the blood)—May increase risk of having kidney failure.
  • Blood clotting problems (eg, thrombosis) or
  • Heart or blood vessel disease (eg, arteriosclerosis) or
  • Hypertension (high blood pressure) or
  • Hyperthyroidism (overactive thyroid) or
  • Kidney disease, severe or
  • Liver disease or
  • Pheochromocytoma (adrenal problem) or
  • Sickle cell anemia (inherited blood disorder)—Use with caution. May make these conditions worse.
  • Homocystinuria (genetic disease)—Patients with this condition should avoid undergoing angiography because of the increased risk of having blood clotting problems.
  • Infection—Iohexol injection should not be given for myelography in patients with this condition.

Proper Use of This Medicine:

A doctor or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle placed in an artery or a vein, or into your spinal cord. It may also be given by mouth or through your rectum.

Your doctor may also give you medicines (eg, antihistamines, steroids) to prevent allergic reactions.

Drink extra fluids so you will pass more urine while you are receiving this medicine. This may help prevent kidney problems.

Precautions While Using This Medicine:

It is very important that your doctor check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.

Tell your doctor if you are pregnant.

This medicine may cause heart attack, stroke, and blood clotting problems during angiographic procedures. Tell your doctor right away if you have chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, nausea, unusual sweating, faintness, coughing up blood, numbness or weakness in your arm or leg, or on one side of your body, sudden or severe headache, or problems with vision, speech, or walking after receiving this medicine.

Severe kidney problems may occur after receiving this medicine. Tell your doctor right away if you have the following symptoms after receiving the medicine: agitation, confusion, decreased urine output, dizziness, headache, muscle twitching, rapid weight gain, or swelling of the face, ankles, or hands.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor or nurse right away if you have a skin rash, itching, shortness of breath, sweating, swelling of the face, tongue, and throat, or tightness in the chest after you receive this medicine.

Make sure your doctor knows if you have had an allergic reaction to any dye or medicine given during a test or procedure.

While using this medicine, you may be exposed to radiation. Talk with your doctor if you have concerns about this.

Make sure any doctor or dentist who treats you knows that you are using iohexol injection. This medicine may affect the results of certain medical tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. You should not receive iohexol injection together with a steroid medicine into your spinal cord.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common—Oral or rectal route
Swelling or pain
Less common—Intravascular route
Arm, back, or jaw pain
chest pain or discomfort
chest tightness or heaviness
difficulty breathing
dizziness
fainting
fast, slow, or irregular heartbeat
nausea
shortness of breath
sweating
swelling in the throat
Less common—Oral or rectal route
Blurred vision
confusion
dizziness
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
headache
nervousness
pounding in the ears
slow or fast heartbeat
sweating
unusual tiredness or weakness
Rare—Intrathecal route
Blurred vision
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
confusion
dizziness or lightheadedness
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
feeling of constant movement of self or surroundings
headache
nervousness
pounding in the ears
seizures
slow or fast heartbeat
sweating
unusual tiredness or weakness
Rare—Intravascular route
Blurred vision
confusion
dilated neck veins
dizziness or lightheadedness
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
extreme fatigue
fast, pounding, or irregular heartbeat or pulse
feeling cold
feeling of constant movement of self or surroundings
fever
irregular breathing
pale skin
seizures
sensation of spinning
swelling of the face, fingers, feet, or lower legs
troubled breathing with exertion
unusual bleeding or bruising
unusual tiredness or weakness
weight gain
Rare—Oral or rectal route
Muscle weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common—Intrathecal route
Nausea
pain in the neck, back, or nerve
More common—Oral or rectal route
Abdominal or stomach pain
bloated or full feeling
diarrhea
excess air or gas in the stomach or intestines
nausea
passing gas
vomiting
Less common—Intrathecal route
Vomiting
Less common—Intravascular route
Bad, unusual, or unpleasant (after) taste
change in taste
headache
Less common—Oral or rectal route
Hives or welts, itching, or skin rash
redness of the skin
sleepiness or unusual drowsiness
Rare—Intrathecal route
Change in color vision
continuing ringing or buzzing or other unexplained noise in the ears
difficulty seeing at night
drowsiness
hearing loss
increased sensitivity of the eyes to sunlight
loss of appetite
sensation of spinning
Rare—Intravascular route
Acid or sour stomach
anxiety
belching
chills
cold sweats
coma
cool, pale skin
cough
depression
diarrhea
dry mouth
heartburn
hives or welts, itching, or rash
increased hunger
indigestion
nightmares
redness of the skin
runny nose
shakiness
sleepiness or unusual drowsiness
slurred speech
sneezing
stomach discomfort, upset, or pain
stuffy nose
uncontrolled eye movements
vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 7/4/2017
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