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Health Guide

Carfilzomib (Intravenous route)

Pronunciation:

kar-FILZ-oh-mib

Brand Names:

  • Kyprolis

Dosage Forms:

  • Powder for Solution

Classifications:

Therapeutic—

Antineoplastic Agent

Pharmacologic—

Proteasome Inhibitor

Uses of This Medicine:

Carfilzomib injection is used alone or together with other medicines (eg, dexamethasone, lenalidomide) to treat multiple myeloma (a type of bone marrow cancer) in patients who have received other treatments that did not work well. It interferes with the growth of cancer cells, which are eventually destroyed by the body. Carfilzomib is an antineoplastic agent (cancer medicine).

This medicine is to be given only by or under the supervision of your doctor.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies have not been performed on the relationship of age to the effects of carfilzomib injection in the pediatric population. Safety and efficacy have not been established.

Older adults—

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of carfilzomib injection in the elderly.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Measles Virus Vaccine, Live
  • Mumps Virus Vaccine, Live
  • Rotavirus Vaccine, Live
  • Rubella Virus Vaccine, Live
  • Varicella Virus Vaccine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Adenovirus Vaccine
  • Bacillus of Calmette and Guerin Vaccine, Live
  • Cholera Vaccine, Live
  • Influenza Virus Vaccine, Live
  • Poliovirus Vaccine, Live
  • Smallpox Vaccine
  • Typhoid Vaccine
  • Yellow Fever Vaccine

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Angina or
  • Blood clots or
  • Cardiomyopathy (heart disease) or
  • Congestive heart failure or
  • Deep vein thrombosis (blood clot in leg) or
  • Heart attack, recent or
  • Heart disease or
  • Hypertension (high blood pressure) or
  • Interstitial lung disease or
  • Kidney disease or
  • Liver disease or
  • Lung or breathing problems or
  • Pneumonitis (lung inflammation) or
  • Pulmonary edema (lung disease) or
  • Pulmonary embolism (blood clot in lung) or
  • Pulmonary hypertension (lung disease) or
  • Thrombocytopenia (low platelets in the blood)—Use with caution. May make these conditions worse.
  • Dehydration or
  • Electrolyte imbalance—Use with caution. May cause side effects to become worse.
  • Herpes zoster—May cause infection to come back (reactivate).

Proper Use of This Medicine:

A nurse or other trained health professional will give you this medicine in a hospital or cancer clinic. This medicine is given through a needle placed in a vein.

This medicine needs to be given on a fixed schedule. Be sure to keep all appointments.

Drink extra fluids so you will pass more urine while you are receiving this medicine. This may help prevent kidney problems and other unwanted effects.

You might also receive medicines (eg, dexamethasone, antivirals) to help prevent unwanted reactions to the injection and decrease the risk of virus infection (eg, herpes zoster) reactivation.

Precautions While Using This Medicine:

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control during treatment and for at least 30 days after the last dose to keep from getting pregnant. Male patients must also use an effective form of birth control to prevent pregnancy in a sexual partner during treatment and for at least 90 days after the last dose. If you think a pregnancy has occurred while receiving this medicine, tell your doctor right away.

This medicine may cause serious heart problems. Tell your doctor right away if you have chest pain or tightness, decrease in amount of urine, dilated neck veins, extreme fatigue, irregular heartbeats, swelling of the face, fingers, feet, or lower legs, troubled breathing, or weight gain while you are receiving this medicine.

Check with your doctor right away if you have a bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, troubled breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem.

This medicine may cause a serious reaction called tumor lysis syndrome (TLS). Call your doctor right away if you have a change in how much or how often you urinate, rapid weight gain, muscle or joint pain, swelling of the feet or lower legs, or feel tired.

Serious lung or breathing problems may occur after you get a shot of this medicine into one of your veins. Call your doctor right away if have any changes in your breathing after you receive this medicine.

Your blood pressure might get too high while you are using this medicine. This may cause headaches, dizziness, or blurred vision. You might need to measure your blood pressure at home. If you think your blood pressure is too high, call your doctor right away.

Blood clots may occur while you are receiving this medicine. Tell your doctor right away if you have chest pain, dizziness or lightheadedness, fainting, fast heartbeat, pain, redness, or swelling in the arm or legs, sudden shortness of breath, or trouble breathing.

This medicine may cause infusion-related reactions, which can be life-threatening and require immediate medical attention. Tell your doctor right away if you start to have a fever, chills or shaking, dizziness, trouble breathing, itching or rash, or lightheadedness or fainting while you are receiving this medicine.

This medicine can lower the number of platelets in your blood, which are needed for blood clotting. This may cause serious bleeding problems. Check with your doctor right away if you notice any unusual bleeding or bruising, black, tarry stools, or pinpoint red spots on your skin.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Tell your doctor right away if you have seizures, headache, confusion, vision problems, unusual drowsiness, tiredness, or weakness. These could be symptoms of a serious nervous system problem, called posterior reversible encephalopathy syndrome (PRES).

This medicine may cause some people to become dizzy or drowsy. Make sure you know how to react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
Agitation
black, tarry stools
bleeding gums
bloating or swelling of the face, arms, hands, lower legs, or feet
blood in the urine or stools
blurred vision
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
chest pain
coma
confusion
cough or hoarseness
decreased urine output
depression
difficult or labored breathing
difficulty with moving
dizziness
drowsiness
fast, slow, or irregular heartbeat
headache
hostility
irregular heartbeat
irritability
lower back or side pain
muscle spasms (tetany) or twitching
nausea or vomiting
numbness or tingling in the hands, feet, or lips
painful or difficult urination
pale skin
pinpoint red spots on the skin
pounding in the ears
rapid weight gain
seizures
stupor
tightness in the chest
tingling of the hands or feet
trembling
troubled breathing with exertion
ulcers, sores, or white spots in the mouth
unsteadiness or awkwardness
unusual bleeding or bruising
unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
unusual tiredness or weakness
unusual weight gain or loss
Less common
Chills
fever
muscle pain or cramps
painful blisters on the trunk of the body
weakness in the arms, hands, legs, or feet
Rare
Dark-colored urine
general feeling of discomfort or illness
general feeling of tiredness or weakness
light-colored stools
stomach pain, continuing
thickening of bronchial secretions
yellow eyes or skin
Incidence not known
Blindness
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
fainting
joint pain, stiffness, or swelling
stomach pain
sweating

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Back pain
body aches or pain
bone pain
constipation
diarrhea
dry mouth
ear congestion
flushed, dry skin
fruit-like breath odor
increased hunger
increased thirst
increased urination
loss of appetite
loss of voice
metallic taste
muscle weakness
pain in the arms or legs
runny nose
sneezing
sore throat
trouble sleeping
weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 9/4/2017
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