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Asparaginase erwinia chrysanthemi (Injection route)

Pronunciation:

as-PAR-a-jin-ase er-WIN-ee-ah kri-SAN-them-ee

Brand Names:

  • Erwinaze

Dosage Forms:

  • Powder for Solution

Classifications:

Therapeutic

Antineoplastic Agent

Pharmacologic

Asparaginase

Uses of This Medicine:

Asparaginase Erwinia chrysanthemi is used together with other cancer medicines to treat a certain type of blood cancer called acute lymphoblastic leukemia (ALL). This medicine is used in patients who have had an allergic reaction to E. coli-derived asparaginase.

Asparaginase Erwinia chrysanthemi belongs to the group of medicines known as antineoplastic agents. It interferes with the growth of the cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by this medicine, other effects will also occur. Some of these may be serious and must be reported to your doctor.

Before you begin treatment with Erwinaze®, you and your doctor should talk about the benefits of this medicine as well as the risks of using it.

This medicine is to be given only by or under the immediate supervision of your doctor.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of Erwinaze® in children.

Older adults

Appropriate studies have not been performed on the relationship of age to the effects of Erwinaze® in the geriatric population. Safety and efficacy have not been established.

Pregnancy

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast-feeding

Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

Other medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Rotavirus Vaccine, Live

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Adenovirus Vaccine Type 4, Live
  • Adenovirus Vaccine Type 7, Live
  • Bacillus of Calmette and Guerin Vaccine, Live
  • Influenza Virus Vaccine, Live
  • Measles Virus Vaccine, Live
  • Methotrexate
  • Mumps Virus Vaccine, Live
  • Poliovirus Vaccine, Live
  • Prednisolone
  • Prednisone
  • Rubella Virus Vaccine, Live
  • Smallpox Vaccine
  • Typhoid Vaccine
  • Varicella Virus Vaccine
  • Vincristine
  • Vincristine Sulfate Liposome
  • Yellow Fever Vaccine

Other interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bleeding problems caused by L-asparaginase treatment, history of or
  • Blood clotting problems caused by L-asparaginase treatment, history of or
  • Pancreatitis caused by L-asparaginase treatment, history of Should not be given to patients with these conditions.
  • Bleeding problems or
  • Blood clotting problems or
  • Diabetes or
  • Hyperglycemia (high blood sugar) or
  • Pancreatitis (inflammation of the pancreas) Use with caution. May make these conditions worse.

Proper Use of This Medicine:

A doctor or other trained health professional will give you this medicine in a hospital or cancer treatment center. This medicine is given as a shot into a muscle or a vein.

Erwinaze® is sometimes given together with other medicines. If you are receiving a combination of medicines, it is important that you receive each one at the proper time. If you are taking some of these medicines by mouth, ask your doctor to help you plan to take them at the right times.

Missed dose

This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Precautions While Using This Medicine:

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor or nurse right away if you have chills, fever, lightheadedness, dizziness, or fainting, fast, pounding heartbeat, swelling of the face, tongue, and throat, or trouble breathing after you receive the medicine.

Pancreatitis may occur while you are using this medicine. Tell your doctor right away if you have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.

Check with your doctor right away if you start having increased thirst or hunger, increased urination, pale skin, nausea, sweating, or faintness. These may be signs that you are having problems with the amount of blood sugar in your body.

Tell your doctor right away if you develop confusion, headache, nausea and vomiting, numbness or tingling in the arms or legs, or chest pain after receiving this medicine. These may be symptoms of a serious bleeding or blood clotting problem.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
Cough
difficulty with swallowing
dizziness
fast heartbeat
fever
hives or welts, itching, or rash
hoarseness
irritation
joint pain, stiffness, or swelling
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
redness of the skin
swelling of the eyelids, face, lips, hands, or feet
tightness in the chest
troubled breathing or swallowing
unusual tiredness or weakness
Less common
Abdominal or stomach pain
bloating
blurred vision
chills
constipation
dark urine
dry mouth
flushed, dry skin
fruit-like breath odor
increased hunger
increased thirst
increased urination
indigestion
loss of appetite
nausea
pains in the chest, groin, or legs, especially calves of the legs
pains in the stomach, side, or abdomen, possibly radiating to the back
seizures
severe headaches of sudden onset
sudden loss of coordination
sudden onset of slurred speech
sudden vision changes
sweating
unexplained weight loss
vomiting
yellow eyes or skin
Rare
Blood in the urine or stools
bruising
confusion
coughing or vomiting blood
headache
numbness or tingling in the face, arms, or legs
persistent bleeding or oozing from puncture sites, mouth, or nose
red streaks on the skin
swelling, tenderness, or pain at the injection site
trouble speaking, thinking, or walking

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
Diarrhea

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 9/15/2016
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