Health Guide

Sodium tetradecyl sulfate (Intravenous route)


SOE-dee-um tet-ra-DEK-ul SUL-fate

Brand Names:

  • Sotradecol

Dosage Forms:

  • Solution



Sclerosing Agent

Uses of This Medicine:

Sodium tetradecyl sulfate is a type of medicine called a sclerosing agent. It is used for the treatment of small varicose veins of the lower extremities.

This medicine is available only with your doctor's prescription.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of sodium tetradecyl sulfate in children with use in other age groups.

Older adults—

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing the use of sodium tetradecyl sulfate in the elderly with use in other age groups.


Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

The presence of other medical problems may affect the use of sodium tetradecyl sulfate. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergic conditions or
  • Bedridden or
  • Cellulitis or
  • Deep vein incompetence or
  • Huge superficial veins with connections to deeper veins or
  • Infections or
  • Phlebitis migrans or
  • Respiratory diseases or
  • Skin diseases or
  • Thrombophlebitis or
  • Valvular vein incompetence or
  • Varicosities caused by abdominal and pelvic tumors (unless the tumor has been removed)—Sodium tetradecyl sulfate should not be administered.
  • Asthma or
  • Blood dyscrasias or
  • Diabetes or
  • Hyperthyroidism or
  • Neoplasm or
  • Sepsis or
  • Tuberculosis—Sodium tetradecyl sulfate should not be administered.
  • Peripheral arteriosclerosis or
  • Thromboangiitis obliterans (Buerger's disease)—Extreme caution should be used; sodium tetradecyl sulfate may make these conditions worse.

Proper Use of This Medicine:

It is important to have a preinjection evaluation.

It is important to give slow injections with a small amount (not over 2 milliliters) of sodium tetradecyl sulfate solution.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage form:
    • For varicose veins:
      • Adults—0.5 to 2 milliliters injected into the vein, depending on the size and degree of varicosity.
      • Children—Use and dose must be determined by your doctor.

Precautions While Using This Medicine:

Embolisms (i.e., blood clots) may occur up to 4 weeks following injection of sodium tetradecyl sulfate.

It is possible that deep vein thrombosis (i.e., blood clot in a deep vein) can develop.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Frequency not known
chest pain
difficulty breathing
difficulty swallowing
dizziness or light-headedness
fast heartbeat
noisy breathing
pain, redness, or swelling in arm or leg
puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
raised red swellings on the skin, lips, tongue, or in the throat
redness of skin
skin rash
sudden shortness of breath or troubled breathing
tightness in chest
unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Frequency not known
pain, local
pain or redness at site of injection
pale skin at site of injection
peeling or sloughing of skin
ulceration at site of injection

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Last Updated: 9/4/2017
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