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Anidulafungin (Intravenous route)

Pronunciation:

ay-nid-ue-la-FUN-jin

Brand Names:

  • Eraxis

Dosage Forms:

  • Powder for Solution

Classifications:

Therapeutic—

Antifungal

Pharmacologic—

Glucan Synthesis Inhibitor

Chemical—

Echinocandin

Uses of This Medicine:

Anidulafungin is an antifungal medicine. It is used to treat fungal infections in the blood, abdomen or stomach, and esophagus (part of your throat where food passes from the pharynx to the stomach).

This medicine is to be given only by or under the direct supervision of a doctor.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies have not been performed on the relationship of age to the effects of anidulafungin injection in children 16 years of age and younger. Safety and efficacy have not been established.

Older adults—

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of anidulafungin injection in the elderly.

Pregnancy—

Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergies to other echinocandin antifungal drugs (e.g., caspofungin [Cancidas®], micafungin [Mycamine®])—Should not be used in patients with this condition.
  • Liver problems—Use with caution. May make this condition worse.

Proper Use of This Medicine:

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in a vein and given over 45 minutes to 3 hours, depending on your dose

Precautions While Using This Medicine:

It is very important that your doctor check you closely while you are receiving this medicine. This is to make sure the medicine has worked properly. Blood tests may be needed to check for unwanted effects.

Tell your doctor right away if you have any symptoms of liver problems including dark-colored urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, or yellow skin or eyes.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine.

It is important to tell your doctor if you are pregnant, planning to become pregnant.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common
Black, tarry stools
chills
cough
decreased urine
dry mouth
fever
increased thirst
irregular heartbeat
loss of appetite
lower back or side pain
mood or mental changes
muscle pain or cramps
nausea or vomiting
numbness or tingling in the hands, feet or lips
painful or difficult urination
pale skin
seizures
shortness of breath
sore throat
sores, ulcers, or white spots on the lips or in the mouth
unusual bleeding or bruising
unusual tiredness or weakness
Rare
Abdominal or stomach pain
back pain
bleeding gums
blood in the urine or stools
bloody stools
bluish color of skin
blurred or loss of vision
changes in skin color
chest pain
chest tightness
clay-colored stools
constipation
dark urine
depression
diarrhea
dizziness
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
drowsiness
extra heartbeats
fainting
fast heartbeat
flushed, dry skin
flushing
fruit-like breath odor
headache
hives or welts
incoherent speech
increased hunger
increased urination
irregular fast heartbeat
irritability
itching
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
metallic taste
muscle spasms (tetany) or twitching
muscle weakness
nervousness
pain, redness, or swelling in the arm or leg
pain, tenderness, and swelling of foot or leg
pinpoint red spots on the skin
pounding in the ears
redness of the skin
restlessness
skin rash
slow heartbeat
sore mouth or tongue
sweating
swelling of the feet or lower legs
swollen glands
trembling
trouble breathing
unexplained weight loss
unpleasant breath odor
unusually warm skin
vomiting of blood
weakness
weight loss
white patches in the mouth or throat or on the tongue
white patches with diaper rash
yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare
Acid or sour stomach
belching
bloating or swelling of the face, arms, hands, lower legs, or feet
disturbed color perception
double vision
eye pain
feeling of warmth
feeling unusually cold
halos around light
indigestion
loss of bowel control
night blindness
over bright appearance of lights
rapid weight gain
redness of the face, neck, arms, and occasionally, upper chest
shivering
stomach discomfort or upset
tingling of the hands or feet
tunnel vision
unusual weight gain or loss
upper stomach pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 8/4/2017
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