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Desflurane (Inhalation route)

Pronunciation:

des-FLOO-rane

Brand Names:

  • Suprane

Dosage Forms:

  • Liquid
  • Solution

Classifications:

Therapeutic—

Volatile Liquid

Chemical—

Haloalkane

Uses of This Medicine:

Desflurane belongs to the group of medicines known as general anesthetics. Inhaled desflurane is used to cause general anesthesia (loss of consciousness) before and during surgery in adults. It is also used as a maintenance anesthesia in adults and children after receiving other anesthetics before and during surgery.

This medicine is to be given only by or under the direct supervision of a trained doctor .

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of inhaled desflurane in children after receiving other anesthetics. However, children 6 years of age and younger are more likely to have unwanted side effects, such as coughing, chest tightness, or trouble breathing, which may require caution in patients receiving this medicine.

Older adults—

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of inhaled desflurane in the elderly. However, elderly patients are more likely to have unwanted effects, which may require a dose adjustment in patients receiving this medicine.

Pregnancy—

Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alfentanil
  • Cisatracurium
  • Nitrous Oxide
  • St John's Wort

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Asthma or
  • Diseases that can cause muscle weakness (eg, familial periodic paralysis, Duchenne muscular dystrophy, myasthenia gravis, Eaton-Lambert syndrome), or history of or
  • Heart or blood vessel disease or
  • Hyperkalemia (high potassium in the blood) or
  • Upper airway infection, recent—The chance of side effects may be increased.
  • Liver disease (eg, cirrhosis, viral hepatitis)—Your doctor may want to use another anesthetic in patients with these conditions.
  • Liver disease (moderate or severe), history of or
  • Malignant hyperthermia, known or suspected—Should not be used in patients with these conditions.

Proper Use of This Medicine:

A doctor or other trained health professional will give you this medicine in a hospital. This medicine is given via a vaporizer and breathed in through your mouth.

Your doctor will give you some medicines before receiving Suprane®.

Precautions While Using This Medicine:

Your doctor will check you closely after receiving this medicine. This will allow your doctor to see if the medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Hyperkalemia may occur rarely after receiving this medicine. Tell your doctor right away if you have confusion, irregular heartbeat, nausea or vomiting, numbness or tingling in the hands, feet, or legs, or trouble breathing after receiving this medicine.

Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.

For patients going home within 24 hours after receiving a general anesthetic:

  • General anesthetics may cause some people to feel drowsy, tired, or weak for a while after they have been given. They may also cause problems with coordination and one's ability to think. Therefore, for about 24 hours (or longer if necessary) after receiving a general anesthetic, do not drive, use machines, or do anything else that could be dangerous if you are not alert.
  • Unless otherwise directed by your doctor or dentist, do not drink alcoholic beverages or take other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness) for about 24 hours after you have received a general anesthetic. To do so may add to the effects of the anesthetic. Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds, other sedatives, tranquilizers, or sleeping medicine, prescription pain medicine or narcotics, medicine for seizures or barbiturates, and muscle relaxants.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
Bluish lips or skin
body aches or pain
congestion
cough
dryness or soreness of the throat
fever
hoarseness
not breathing
runny nose
tender, swollen glands in the neck
tightness in the chest
trouble breathing
trouble swallowing
voice changes
Less common
Blurred vision
chest pain or discomfort
dizziness
fast, pounding, or irregular heartbeat or pulse
headache
lightheadedness, dizziness, or fainting
nervousness
pounding in the ears
slow or irregular heartbeat
unusual tiredness
Rare
Dark urine
difficulty with moving
feeling of warmth or heat
flushing or redness of the skin, especially on the face and neck
general tiredness and weakness
joint pain
light-colored stools
muscle aching or cramping
muscle pains or stiffness
nausea and vomiting
noisy breathing
pain or discomfort in the arms, jaw, back, or neck
sweating
swollen joints
upper right abdominal or stomach pain
yellow eyes and skin
Incidence not known
Abdominal or stomach pain
confusion
convulsions
decreased urine
dry mouth
increased thirst
loss of appetite
no blood pressure or pulse
numbness or tingling in the hands, feet, or lips
stopping of heart
unconsciousness
weakness or heaviness of the legs

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
Increased watering of the mouth
redness of the white part of the eyes or inside of the eyelids
Rare
Anxiety
hyperventilation
irritability
itching skin
restlessness
shaking
trouble sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 9/4/2017
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