Health Guide

Quinupristin and dalfopristin (Intravenous route)


kwin-ue-PRIS-tin, dal-foe-PRIS-tin

Brand Names:

  • Synercid

Dosage Forms:

  • Powder for Solution






Uses of This Medicine:

Quinupristin and dalfopristin injection is used to treat infections of the skin and the blood. It may also be used for other conditions as determined by your doctor. It is given by injection and is used mainly for serious infection for which other medicine may not work.

Quinupristin and dalfopristin belong to the family of medicine called antibiotics. Antibiotics are medicines used in the treatment of infections caused by bacteria. They work by killing bacteria or preventing their growth. Quinupristin and dalfopristin will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of quinupristin and dalfopristin injection in children younger than 16 years of age. Safety and efficacy have not been established.

Older adults—

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of quinupristin and dalfopristin injection in the elderly.


Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Astemizole
  • Atorvastatin
  • Cerivastatin
  • Cholera Vaccine, Live
  • Fluvastatin
  • Haloperidol
  • Lovastatin
  • Pravastatin
  • Simvastatin
  • Tacrolimus
  • Vinblastine
  • Vincristine
  • Vincristine Sulfate Liposome
  • Vinorelbine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Carbamazepine
  • Cyclosporine
  • Delavirdine
  • Diazepam
  • Diltiazem
  • Disopyramide
  • Docetaxel
  • Felodipine
  • Indinavir
  • Isradipine
  • Lacidipine
  • Lidocaine
  • Manidipine
  • Methylprednisolone
  • Midazolam
  • Nevirapine
  • Nicardipine
  • Nifedipine
  • Nilvadipine
  • Nimodipine
  • Nisoldipine
  • Paclitaxel
  • Quinidine
  • Ritonavir
  • Verapamil

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Colitis (inflammation of the colon) or
  • Diarrhea, severe—Use with caution. May make these conditions worse.
  • Liver disease—Liver disease may increase blood levels of this medicine, increasing the chance of side effects.

Proper Use of This Medicine:

A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle placed in one of your veins. The medicine must be injected slowly, so your IV tube will need to stay in place for 60 minutes.

To help clear up your infection completely, this medicine must be given for the full time of treatment, even if you begin to feel better after a few days. Also, it works best when there is a constant amount in the blood. To help keep the amount constant, quinupristin and dalfopristin must be given on a regular schedule.

Precautions While Using This Medicine:

Your doctor will check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood tests may be needed to check for unwanted effects.

If your symptoms do not improve or if they become worse, call your doctor.

This medicine may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop receiving this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
Swelling, redness, or pain at the injection site
Less common
Changes in skin color
dry, red, hot, or irritated skin
joint pain
muscle pain
redness, burning sensation, or pain under the skin usually in the injection site
swelling of the foot or leg
back, leg, or stomach pains
black, tarry stools
bleeding gums
bloating or swelling of the face, arms, hands, lower legs, or feet
blood in the urine
bloody, black, or tarry stools
blue lips, fingernails, or skin
blurred vision
bone pain
burning, tingling, numbness, or pain in the hands, arms, feet, or legs
chest pain or discomfort
chest pain, possibly moving to the left arm, neck, or shoulder
convulsions or seizures
cough or hoarseness
darkened urine
decreased urine output
difficult, fast, or labored breathing
difficult or painful urination
difficulty with moving
difficulty with swallowing
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
extremely shallow or slow breathing
fast, slow, irregular, pounding, or racing heartbeat or pulse
feeling of warmth or heat
flushing or redness of the skin, especially on the face and neck
general body swelling
general tiredness and weakness
high fever
inability to speak
increased thirst
light-colored stools
loss of appetite
loss of bladder control
loss of consciousness
loss of strength or energy
lower back or side pain
muscle pain or cramps
muscle stiffness or weakness
nausea or vomiting
no blood pressure or pulse
not breathing
pain in the joints
pains in the stomach, side, or abdomen, possibly radiating to the back
pale skin
problems with bleeding or clotting
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
rapid weight gain
redness, burning sensation, or pain in the vagina
sensation of pins and needles
severe bloody diarrhea
severe or sudden headache
shakiness in the legs, arms, hands, or feet
shortness of breath
skin rash
skin rash with red patches
slurred speech
sore throat
sores on the skin
sores, ulcers, or white spots on the lips or in the mouth
stabbing pain
stiff neck
stopping of the heart
swelling of the face, ankles, or hands
swollen glands
temporary blindness
tightness in the chest
tingling of the hands or feet
total body jerking
trembling or shaking of the hands or feet
troubled breathing
unexplained bleeding or bruising
unusual tiredness or weakness
unusual weight gain or loss
upper right abdominal or stomach pain
vomiting of blood or material that looks like coffee grounds
weakness in the arm or leg on one side of the body, sudden and severe
worsening of the underlying disease
yellowing of the eyes or skin
Incidence not known
Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Acid or sour stomach
ankle, knee, or great toe joint pain
cold sweats
cool, pale skin
cramps in the legs
excessive muscle tone
hives or welts
increased hunger
itching of the vagina or genital area
joint stiffness or swelling
lower back or side pain
muscle tension or tightness
pain during sexual intercourse
redness of the skin
stomach discomfort, upset, or pain
swelling or inflammation of the mouth
thick, white vaginal discharge with no odor or with a mild odor
trouble sleeping
unable to sleep
white patches in the mouth, tongue, or throat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Last Updated: 9/4/2017
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