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Benzhydrocodone/acetaminophen (By mouth)

Acetaminophen (a-seet-a-MIN-oh-fen), Benzhydrocodone (benz-hye-droe-KOE-done)

Treats pain. This medicine contains a narcotic pain reliever.

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to acetaminophen, benzhydrocodone, or hydrocodone, or severe lung or breathing problems (including asthma) or stomach or bowel blockage (including paralytic ileus).

How to Use This Medicine:

Tablet

  • Your doctor will tell you how much medicine to use. Do not use more than directed.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: If you miss a dose, take your next dose at your usual time.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Flush any unused or expired tablets down the toilet.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine if you are using or have used an MAO inhibitor within the past 14 days.
  • Some medicines can affect how benzhydrocodone/acetaminophen works. Tell your doctor if you are using any of the following:
    • Carbamazepine, erythromycin, ketoconazole, phenytoin, rifampin, ritonavir
    • Diuretic (water pill)
    • Medicine to treat depression or mental health problems
    • Triptan medicine to treat migraine headaches
  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol. Tell your doctor if you are using buprenorphine, butorphanol, nalbuphine, pentazocine, or a muscle relaxer.
  • Do not drink alcohol while you are using this medicine. Acetaminophen can damage your liver, and your risk is higher if you also drink alcohol.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, lung or breathing problems, adrenal problems, gallbladder problems, pancreas problems, thyroid problems, stomach problems, or a history of head injury or brain tumor, seizures, mental illness, or drug or alcohol abuse.
  • This medicine may cause the following problems:
    • High risk of overdose, which can lead to death
    • Respiratory depression (serious breathing problem that can be life-threatening)
    • Liver problems
    • Adrenal gland problems
    • Serious skin reactions
    • Seizures
    • Serotonin syndrome (when used with certain medicines)
  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
  • This medicine contains acetaminophen. Read the labels of all other medicines you are using to see if they also contain acetaminophen, or ask your doctor or pharmacist. Do not use more than 4 grams (4,000 milligrams) total of acetaminophen in one day.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.
  • This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, diarrhea, seeing or hearing things that are not there
  • Blistering, peeling, red skin rash
  • Blue lips, fingernails, or skin
  • Cold feeling, tiredness, weight loss
  • Dark urine or pale stools, loss of appetite, nausea, vomiting, stomach pain, yellow skin or eyes
  • Extreme weakness, shallow breathing, slow heartbeat, sweating, seizures, cold or clammy skin
  • Lightheadedness, dizziness, fainting

If you notice these less serious side effects, talk with your doctor:

  • Constipation
  • Headache
  • Sleepiness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 7/4/2018
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