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Lesinurad/allopurinol (By mouth)

Allopurinol (al-oh-PURE-i-nol), Lesinurad (le-SIN-ure-ad)

Treats gout and lowers uric acid levels in the blood.

Brand Name(s):

Duzallo

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use this medicine if you had an allergic reaction to lesinurad or allopurinol, of if you have kidney disease, tumor lysis syndrome, or Lesch-Nyhan syndrome.

How to Use This Medicine:

Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Take this medicine in the morning with food and water.
  • Drink at least 2 liters (68 ounces) of water each day to stay hydrated.
  • Your doctor may give you other medicines before starting treatment with this medicine to prevent flare-ups of gout.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: If you miss a dose of this medicine, skip the missed dose and take your next dose at your usual time. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how lesinurad/allopurinol works. Tell your doctor if you are using any of the following:
    • Amiodarone, aspirin, azathioprine, bleomycin, carbamazepine, chlorpropamide, cyclophosphamide, cyclosporine, dicumarol, doxorubicin, mechloroethamine, mercaptopurine, procarbazine, valproic acid
    • Birth control implants, injections, patches, or pills
    • Diuretic (water pill)
    • Medicine to treat infection (including amoxicillin, ampicillin, fluconazole, rifampin)

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, heart and blood vessel disease, or blood problems.
  • This medicine can cause the following problems:
    • Kidney problems
    • Serious skin reactions
    • Increased risk for heart attack or stroke
    • Liver problems
  • This medicine may make you drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Bloody or black, tarry stools
  • Change in how much or how often you urinate, cloudy urine
  • Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, unusual sweating, faintness
  • Fever, chills, sore throat, cough, body aches
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
  • Pain in your lower leg (calf)
  • Unusual bleeding, bruising, or weakness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 11/4/2017
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