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Empagliflozin/metformin (By mouth)

Empagliflozin (em-pa-gli-FLOE-zin), Metformin (met-FOR-min)

Treats type 2 diabetes. Also used to lower risk of death in patients with type 2 diabetes and heart disease.

Brand Name(s):

Synjardy, Synjardy XR

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to empagliflozin or metformin.

How to Use This Medicine:

Tablet, Long Acting Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • It is best to take this medicine with food or milk.
  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how empagliflozin/metformin works. Tell your doctor about all other medicines that you are using, including the following:
    • Acetazolamide, amiloride, cimetidine, dichlorphenamide, digoxin, dolutegravir, morphine, procainamide, quinidine, quinine, ranitidine, ranolazine, topiramate, triamterene, trimethoprim, vancomycin, vandetanib, zonisamide
    • Blood pressure medicine
    • Diuretic (water pill)
    • NSAID pain or arthritis medicine (including aspirin, celecoxib, diclofenac, ibuprofen, naproxen)
  • Limit the amount of alcohol you drink.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding. If you had problems ovulating or have irregular periods, this medicine may cause you to ovulate, which could lead to pregnancy if you are sexually active. Talk to your doctor about effective birth control while you are using this medicine.
  • Tell your doctor if have kidney disease, liver disease, heart failure, high cholesterol, adrenal or pituitary gland problem, vitamin B12 deficiency, or a history of pancreas problems or urinary tract or genital yeast infections. Tell your doctor if you are on a low-salt diet.
  • This medicine may cause the following problems:
    • Lactic acidosis (too much acid in the blood)
    • Low blood pressure
    • Ketoacidosis (high ketones and acid in the blood)
    • Low blood sugar levels
    • Kidney damage
    • Increased risk of genital yeast or urinary tract infections
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may interact with the dye used for an x-ray or a CT scan.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Change in how much or how often you urinate, bloody urine, difficult or painful urination, lower back or side pain, fever, chills
  • Fast breathing, trouble breathing, nausea and vomiting, stomach pain, severe weakness, tiredness
  • Lightheadedness, dizziness, fainting
  • Shaking, trembling, sweating, fast or pounding heartbeat, faintness, hunger, confusion

If you notice these less serious side effects, talk with your doctor:

  • Redness, itching, pain, or swelling of the penis, bad-smelling discharge from the penis
  • White or yellow vaginal discharge, vaginal itching or odor

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 9/4/2017
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