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Isavuconazonium (By injection)

Isavuconazonium Sulfate (eye-sa-vue-koe-na-ZOE-nee-um SUL-fate)

Treats fungal infections.

Brand Name(s):

Cresemba

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to isavuconazonium.

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • A nurse or other health provider will give you this medicine.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine together with carbamazepine, ketoconazole, phenobarbital, rifampin, ritonavir, or St John's wort.
  • Some foods and medicines can affect how isavuconazonium works. Tell your doctor if you are using any of the following:
    • Atorvastatin
    • Bupropion
    • Cyclosporine
    • Digoxin
    • Lopinavir/ritonavir
    • Midazolam
    • Mycophenolate mofetil
    • Sirolimus
    • Tacrolimus

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease or heart rhythm problems (such as familial short QT syndrome). Tell your doctor if you had an allergic reaction to similar medicines (including itraconazole, ketoconazole, voriconazole).
  • This medicine may cause liver problems.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Chills, dizziness, trouble breathing
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Decrease in how much or how often you urinate, difficult or painful urination
  • Dry mouth, increased thirst, muscle cramps, uneven heartbeat
  • Lightheadedness, dizziness, or fainting
  • Numbness or tingling, change in sense of touch

If you notice these less serious side effects, talk with your doctor:

  • Headache, trouble sleeping
  • Nausea, vomiting, constipation, diarrhea
  • Rapid weight gain, swelling in your hands, ankles, or feet

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 7/4/2017
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