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Empagliflozin/linagliptin (By mouth)

Empagliflozin (em-pa-gli-FLOE-zin), Linagliptin (lin-a-GLIP-tin)

Treats type 2 diabetes and lowers the risk of death in patients with type 2 diabetes and heart disease.

Brand Name(s):

Glyxambi

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to empagliflozin or linagliptin.

How to Use This Medicine:

Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how empagliflozin/linagliptin works. Tell your doctor if you are using any of the following:
    • Rifampin
    • Blood pressure medicine
    • Diuretic (water pill)
    • Insulin or other diabetes medicine
    • NSAID pain or arthritis medicine (including aspirin, celecoxib, diclofenac, ibuprofen, naproxen)
  • Limit the amount of alcohol you drink.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant. Do not use this medicine during the second and third trimesters of pregnancy, unless your doctor tells you to.
  • Do not breastfeed during treatment with this medicine.
  • Tell your doctor if you have kidney disease, high cholesterol, or a history of pancreas problems, heart failure, or urinary tract or genital yeast infections. Tell your doctor if you drink alcohol or if you are on a low-salt diet.
  • This medicine may cause the following problems:
    • Pancreatitis
    • Heart failure
    • Low blood pressure
    • Ketoacidosis (high ketones and acid in the blood)
    • Kidney problems
    • Low blood sugar
    • Increased risk of genital yeast or urinary tract infections
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Change in how much or how often you urinate, bloody urine, painful or difficult urination
  • Increased hunger, headache, confusion, shaking, trembling, sweating
  • Large, hard skin blisters
  • Lightheadedness, dizziness, or fainting
  • Severe joint pain, lower back or side pain, fever, chills
  • Sudden or severe stomach pain, nausea, vomiting
  • Swelling in your hands, ankles, or feet
  • Trouble breathing, cold sweat, bluish-colored skin

If you notice these less serious side effects, talk with your doctor:

  • Cough, stuffy or runny nose, sore throat
  • Redness, itching, pain, or swelling of the penis, bad-smelling discharge from the penis
  • White or yellowish vaginal discharge, vaginal itching or odor

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 10/4/2017
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