Health Guide

Immune globulin/hyaluronidase human, recombinant (By injection)

Treats problems with your immune system.

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to human immune globulin or hyaluronidase, or if you have an immunoglobulin A (IgA) deficiency.

How to Use This Medicine:


  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin. It is usually given in the stomach or thighs.
  • A nurse or other trained health professional will give you this medicine.
  • You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
  • Use a new needle and syringe each time you inject your medicine.
  • Do not use this medicine in or around an infected or red, swollen area.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Missed dose: Call your doctor, pharmacist, or home health caregiver for instructions.
  • Storage instructions: Store the medicine in the original container in the refrigerator or at room temperature. Protect it from light. Do not freeze. Do not put the medicine back in the refrigerator after you let it warm to room temperature.
  • If you store the medicine in the refrigerator, let it reach room temperature before you use it. Do not heat or shake the medicine.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Talk to your doctor before you get any vaccine. Some vaccines may not work as well while you are using this medicine.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney problems, liver problems, heart problems, blood clotting problems, or diabetes.
  • This medicine may cause the following problems:
    • Blood clots in your heart, lungs, or brain
    • Bleeding
    • Aseptic meningitis syndrome (AMS)
    • Serious kidney problems
    • Serious lung problems
  • This medicine is made from donated human blood. All donated blood is tested for certain viruses. Although your risk for getting a virus from the medicine is very low, talk with your doctor if you have concerns.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Blue lips or fingernails, trouble breathing
  • Change in how much or how often you urinate, rapid weight gain, swelling in your hands, ankles, or feet
  • Chills, cough, fever, sore throat, nausea, or vomiting
  • Pain in your lower leg (calf), numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
  • Stiff neck, headache, nausea, vomiting, fever, eye pain, eye sensitivity to light
  • Unusual bleeding, bruising, or weakness
  • Yellow skin or eyes, urine that is dark, red, or brown

If you notice these less serious side effects, talk with your doctor:

  • Redness or swelling where the needle is placed
  • Tiredness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 11/4/2017
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