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Vorapaxar (By mouth)

Vorapaxar (vor-a-PAX-ar)

Lowers the risk of blood clots in patients who had a heart attack or have reduced blood flow in their legs.

Brand Name(s):

Zontivity

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to vorapaxar, or if you have active bleeding problems (such as ulcers), or a history of stroke.

How to Use This Medicine:

Tablet

  • Your doctor will tell you how much medicine to use. Do not use more than directed. Do not stop taking this medicine without checking first with your doctor.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some foods and medicines can affect how vorapaxar works. Tell your doctor if you are using St John's wort, boceprevir, carbamazepine, conivaptan, nefazodone, phenytoin, rifampin, telaprevir, medicine to treat an infection (such as clarithromycin, itraconazole, ketoconazole, posaconazole, telithromycin), medicine to treat HIV infection (indinavir, nelfinavir, ritonavir, saquinavir), an NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, naproxen, celecoxib), or a blood thinner (such as warfarin).

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, a history of bleeding problems, or you recently had surgery.
  • This medicine may increase your risk for bleeding and bruising.
  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Coughing up blood or vomiting of blood or material that looks like coffee grounds
  • Pink, red, or dark brown urine, red or black stools
  • Unexplained nosebleeds
  • Unusual bleeding, bruising, or weakness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 9/4/2017
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