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Health Guide

Codeine/phenylephrine/promethazine (By mouth)

Codeine Phosphate (KOE-deen FOS-fate), Phenylephrine Hydrochloride (fen-il-EF-rin hye-droe-KLOR-ide), Promethazine Hydrochloride (proe-METH-a-zeen hye-droe-KLOR-ide)

Treats cough and stuffy nose caused by allergies. Codeine is a narcotic pain reliever.

Brand Name(s):

Promethazine VC w/Codeine

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to codeine, phenylephrine, promethazine, or a phenothiazine medicine. This medicine is not meant for use in children younger than 6 years.

How to Use This Medicine:

Syrup

  • Your doctor will tell you how much medicine to use. Do not use more than directed.
  • Oral liquid: Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
  • This medicine is not for long-term use.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine together with a MAO inhibitor.
  • Some medicines can affect how codeine/phenylephrine/promethazine works. Tell your doctor if you are using the following:
    • Atropine, phenylpropanolamine, propranolol
    • Amphetamine
    • Ergot medicines
    • Medicine to treat depression, anxiety, and mental health problems
  • Do not drink alcohol while you are using this medicine.
  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant, or if you have kidney disease, liver disease, Addison disease, bone marrow problems, breathing problems (such as asthma, COPD, sleep apnea), diabetes, enlarged prostate, heart or blood vessel problems, high blood pressure, stomach or bowel problems (such as ulcers, ulcerative colitis), thyroid problems, or a history of head injury or seizures. Tell your doctor if you have glaucoma, you recently had stomach or urinary tract surgery, or you have been addicted to alcohol or drugs.
  • Do not breastfeed while you are using this medicine, unless you have your doctor's permission to do so.
  • This medicine may cause the following problems:
    • High risk of overdose, which can lead to death
    • Respiratory depression
    • Neuroleptic malignant syndrome (NMS)
  • This medicine may make you dizzy, drowsy, or lightheaded. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, or yellow skin or eyes
  • Extreme dizziness, drowsiness, or weakness, shallow breathing, slow or uneven heartbeat, sweating, cold or clammy skin, seizures
  • Fever, confusion, muscle stiffness
  • Lightheadedness, dizziness, fainting
  • Severe constipation or stomach pain

If you notice these less serious side effects, talk with your doctor:

  • Mild constipation
  • Sleepiness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 11/4/2017
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