Trametinib (By mouth)
Treats melanoma (skin cancer).
MekinistThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:This medicine is not right for everyone. Do not use it if you had an allergic reaction to trametinib, or if you are pregnant.
How to Use This Medicine:
- Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
- Your doctor will tell you how much medicine to use. Do not use more than directed.
- Take this medicine at least 1 hour before or 2 hours after a meal.
- Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
- Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose. If your next dose is less than 12 hours away, skip the missed dose and take the medicine at your regular dosing time.
- Store the medicine in the refrigerator in the original bottle. Do not freeze. Keep away from moisture and light.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Warnings While Using This Medicine:
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Birth control pills may not work as well to prevent pregnancy when used with this medicine. Use a second form of birth control along with your pills. Use birth control during treatment and for 4 months after your last dose.
- Tell your doctor if you are breastfeeding, or if you have bleeding problems, blood clots, heart disease, lung disease or breathing problems, high blood pressure, eye problems, stomach or bowel problems (such as perforation), or a history of diabetes.
- This medicine may cause the following problems:
- Bleeding problems or blood clots
- Eye or vision problems
- Heart problems (including heart failure)
- Lung or breathing problems
- Severe skin rash or infections
- High sugar levels in the blood
- This medicine could cause infertility in women. Talk with your doctor before using this medicine if you plan to have children.
- This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Bleeding gums, coughing up blood, unusual nosebleeds, red or dark brown urine, or red or black, tarry stools
- Blurred vision, changes in vision
- Chest pain, trouble breathing, cough, cold sweat, or bluish-colored skin
- Fast, slow, or pounding heartbeat
- Fever, chills, change in how much or how often you urinate
- Increased hunger or thirst
- Numbness or weakness in your arm or leg, or on one side of your body, sudden or severe headache, problems with vision, speech, or walking
- Rapid weight gain, swelling in your hands, ankles, or feet
- Redness, swelling, peeling, or tenderness of the hands or feet
- Severe headache, lightheadedness, or dizziness
- Severe rash, redness, or acne
- Unusual bleeding, bruising, or weakness
If you notice these less serious side effects, talk with your doctor:
- Mild diarrhea, nausea, vomiting, stomach pain
- Sores or white patches on your lips, mouth, or throat
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 7/4/2017
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