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Cabazitaxel (By injection)

Cabazitaxel (ka-baz-i-TAX-el)

Treats prostate cancer.

Brand Name(s):

Jevtana

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to cabazitaxel or polysorbate 80 (a preservative).

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
  • You may also receive other medicines to help prevent allergic reactions and nausea from the injection.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Missed dose: This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how cabazitaxel works. Tell your doctor if you are using any of the following:
    • Atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, or voriconazole
    • Blood thinner (including warfarin)
    • NSAID pain or arthritis medicine (including aspirin, celecoxib, diclofenac, ibuprofen, naproxen)
    • Steroid (including dexamethasone, hydrocortisone, prednisolone)

Warnings While Using This Medicine:

  • Tell your doctor if you have kidney disease, liver disease, anemia, an infection, lung disease, or a history of stomach ulcer or bleeding.
  • This medicine can cause the following problems:
    • Kidney problems
    • Stomach and bowel problems (such as bleeding, perforation, inflammation, or blockage)
    • Lung or breathing problems
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain, cough, trouble breathing
  • Constipation, severe nausea, vomiting, diarrhea, or stomach pain
  • Decrease in how much or how often you urinate, red or dark brown urine
  • Fever, chills, cough, sore throat, and body aches
  • Lightheadedness, dizziness, fainting
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet
  • Swelling in your hands, ankles, feet, or face
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Mild nausea, vomiting, or diarrhea, loss of appetite
  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed
  • Tiredness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 10/4/2017
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