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Clorazepate (By mouth)

Clorazepate (klor-AZ-e-pate)

Treats anxiety, trouble sleeping, symptoms of alcohol withdrawal, and certain types of seizures.

Brand Name(s):

Tranxene T-Tab

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to clorazepate, or you have narrow angle glaucoma.

How to Use This Medicine:

Capsule, Tablet, Long Acting Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how clorazepate works. Tell your doctor if you are using any of the following:
    • Hexobarbital, phenobarbital
    • MAO inhibitor
    • Medicine to treat depression
    • Phenothiazine medicine
    • Benzodiazepine medicine
  • Do not drink alcohol while you are using this medicine.
  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or planning to become pregnant, or if you have kidney disease, liver disease, glaucoma, lung disease or breathing problems, or a history of alcohol or drug abuse, depression, or mental health problems.
  • Do not breastfeed while you are using this medicine.
  • This medicine may cause the following problems:
    • Respiratory depression (serious breathing problem that can be life-threatening), when used with narcotic pain medicines
  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • This medicine can increase thoughts of suicide. Tell your doctor right away if you start to feel depressed and have thoughts about hurting yourself.
  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blue lips, fingernails, or skin
  • Confusion or unusual excitement, nervousness, or irritability
  • Depression, anxiety, irritability, hallucinations, trouble sleeping, unusual behavior, thoughts of hurting yourself or others
  • Extreme drowsiness or weakness, slow heartbeat, trouble breathing

If you notice these less serious side effects, talk with your doctor:

  • Clumsiness, trouble with coordination
  • Dizziness, drowsiness, or sleepiness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 10/4/2017
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