Upper airway biopsy
Upper airway biopsy is surgery to remove a small piece of tissue from the nose, mouth, and throat area. The tissue will be examined under the microscope by a pathologist.
Biopsy - upper airway
How the Test is Performed
The health care provider will spray a numbing medicine in your mouth and throat. A metal tube is inserted to hold your tongue out of the way.
Another numbing medicine flows through the tube down the back of the throat. This may cause you to cough at first. When the area feels thick or swollen, it is numb.
The provider looks at the abnormal area, and removes a small piece of tissue. It is sent to the laboratory for examination.
How to Prepare for the Test
DO NOT eat for 6 to 12 hours before the test.
Tell your provider if you take a blood thinner, such as aspirin, plavix or coumadin, when you schedule the biopsy. You may need to stop taking them for a little while. Never stop taking any medicines without first talking to your provider.
How the Test will Feel
As the area is being numbed, you may feel like there is fluid running down the back of your throat. You may feel the need to cough or gag. And you may feel pressure or mild tugging.
When the numbness wears off, your throat may feel scratchy for several days. After the test, the cough reflex will return in 1 to 2 hours. Then you may eat and drink normally.
Why the Test is Performed
This test may be done if your provider thinks there is a problem with your upper airway. It may also be done with a bronchoscopy.
The upper airway tissues are normal, with no abnormal growths.
What Abnormal Results Mean
Disorders or conditions that may be discovered include:
- Benign (noncancerous) cysts or masses
- Certain infections
- Granulomas and related inflammation (may be caused by tuberculosis)
- Autoimmune disorders, such as Wegener granulomatosis
- Necrotizing vasculitis
Risks for this procedure include:
- Bleeding (some bleeding is common, heavy bleeding is not)
- Breathing difficulties
- Sore throat
There is a risk of choking if you swallow water or food before the numbness wears off.
Frew AJ, Doffman SR, Hurt K, Buxton-Thomas R. Respiratory disease. In: Kumar P, Clark M, eds. Kumar and Clarke's Clinical Medicine. 9th ed. Philadelphia, PA: Elsevier; 2017:chap 24.
Yung RC, Flint PW. Tracheobronchial endoscopy. In: Flint PW, Haughey BH, Lund V, et al, eds. Cummings Otolaryngology: Head & Neck Surgery. 6th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 72.
Reviewed By: Tang Ho, MD, Assistant Professor, Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology – Head and Neck Surgery, The University of Texas Medical School at Houston, Houston, TX. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.