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Burkitt lymphoma

Definition

Burkitt lymphoma (BL) is a very fast growing form of non-Hodgkin lymphoma.

Alternative Names

B-cell lymphoma; High-grade B-cell lymphoma; Small noncleaved cell lymphoma

Causes

BL was first discovered in children in certain parts of Africa. It also occurs in the United States.

The African type of BL is closely associated with the Epstein-Barr virus (EBV), the main cause of infectious mononucleosis. The North American form of BL is not linked to EBV.

People with HIV/AIDS have an increased risk for this condition. BL is most often seen in males.

Symptoms

BL may first be noticed as a swelling of the lymph nodes (glands) in the head and neck. These swollen lymph nodes are often painless, but can grow very rapidly.

In the types commonly seen in the United States, the cancer often starts in the belly area (abdomen). The disease can also start in the ovaries, testes, brain, and spinal fluid.

Other general symptoms may include:

  • Fever
  • Night sweats
  • Unexplained weight loss

Exams and Tests

The health care provider will perform a physical exam. Tests include:

Treatment

Chemotherapy is used to treat this type of cancer. If the cancer does not respond to chemotherapy alone, a bone marrow transplant may be done.

Outlook (Prognosis)

More than one half of people with BL can be cured with intensive chemotherapy. The cure rate may be lower if the cancer spreads to the bone marrow or spinal fluid. The outlook is poor if the cancer comes back after a remission or does not go into remission as a result of the first cycle of chemotherapy.

Possible Complications

Possible complications of BL include:

  • Complications of treatment
  • Spread of the cancer

When to Contact a Medical Professional

Call your provider if you have symptoms of BL.

References

National Cancer Institute. PDQ adult non-Hodgkin lymphoma treatment. Updated June 1, 2016. www.cancer.gov/types/lymphoma/hp/adult-nhl-treatment-pdq#section/all. Accessed July 11, 2016.

National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology (NCCN guidelines): non-Hodgkin lymphoma. Updated May 3, 2016. Version 3.2016. www.nccn.org/professionals/physician_gls/pdf/nhl.pdf. Accessed July 11, 2016.

Roschewski MJ, Wilson WH. Non-Hodgkin lymphoma. In: Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE, eds. Abeloff's Clinical Oncology. 5th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 106.


Review Date: 5/20/2016
Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
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