Post-splenectomy syndrome can occur after surgery to remove the spleen. It consists of a group of symptoms and signs such as:
- Destruction of red blood cells
- Increased risk of severe infections, from bacteria such as Streptococcus pneumoniae and Neisseria meningitidis
- Thrombocytosis (increased platelet count, which can cause blood clots)
Splenectomy - post-surgery syndrome
Possible long-term medical problems include:
- Hardening of the arteries (atherosclerosis)
- Pulmonary hypertension (a disease affecting the blood vessels in your lungs)
Connell NT, Shurin SB, Schiffman FJ. The spleen and its disorders. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, Anastasi J, eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, PA: Elsevier Saunders; 2013:chap 162.
Reviewed By: Rita Nanda, MD, Assistant Professor of Medicine, Section of Hematology/Oncology, University of Chicago Medicine, Chicago, IL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.