Health Guide

Hypothalamic dysfunction


Hypothalamic dysfunction is a problem with part of the brain called the hypothalamus. The hypothalamus helps control the pituitary gland and regulates many body functions.

Alternative Names

Hypothalamic syndromes


The hypothalamus helps keep the body's internal functions in balance. It helps regulate:

  • Appetite and weight
  • Body temperature
  • Childbirth
  • Emotions, behavior, memory
  • Growth
  • Production of breast milk
  • Salt and water balance
  • Sex drive
  • Sleep-wake cycle and the body clock

Another important function of the hypothalamus is to control the pituitary gland. The pituitary is a small gland at the base of the brain. It lies just below the hypothalamus. The pituitary, in turn, controls the:

There are many causes of hypothalamic dysfunction. The most are surgery, traumatic brain injury, tumors, and radiation.

Other causes include:


Symptoms are usually due to the hormones or brain signals that are missing. In children, there may be growth problems, either too much or too little growth. In other children, puberty occurs too early or too late.

Tumor symptoms may include headache or loss of vision.

Hypothyroidism symptoms may include feeling cold all the time, constipation, fatigue, or weight gain, among others.

Low adrenal function symptoms may include fatigue, weakness, poor appetite, weight loss, and lack of interest in activities.

Exams and Tests

The health care provider will perform a physical examination and ask about your symptoms.

Blood or urine tests may be ordered to determine levels of hormones such as:

Other possible tests include:


Treatment depends on the cause of the hypothalamic dysfunction:

  • For tumors, surgery or radiation may be needed.
  • For hormonal deficiencies, missing hormones need to be replaced by taking medicine.

Outlook (Prognosis)

Many causes of hypothalamic dysfunction are treatable. Most of the time, missing hormones can be replaced.

Possible Complications

Complications of hypothalamic dysfunction depend on the cause.


  • Permanent blindness
  • Problems related to the brain area where the tumor occurs
  • Vision disorders
  • Problems controlling salt and water balance



  • Inability to deal with stress (such as surgery or infection), which can be life threatening by causing low blood pressure



  • High cholesterol
  • Osteoporosis
  • Short stature (in children)
  • Weakness

When to Contact a Medical Professional

Call your provider if you have:

  • Headaches
  • Symptoms of hormone excess or deficiency
  • Vision problems


If you have symptoms of a hormonal deficiency, discuss replacement therapy with your provider.


Giustina A, Braunstein GD. Hypothalamic syndromes. In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult and Pediatric. 7th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 10.

Molitch ME. Neuroendocrinology and the neuroendocrine system. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 223.

Review Date: 5/7/2017
Reviewed By: Brent Wisse, MD, Associate Professor of Medicine, Division of Metabolism, Endocrinology & Nutrition, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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